Helper T Cells in Idiopathic Membranous Nephropathy

被引：34

作者：

Zhao, Qihan ^{[1
]}

Dai, Haoran ^{[2
]}

Liu, Xianli ^{[2
]}

Jiang, Hanxue ^{[1
]}

Liu, Wenbin ^{[3
]}

Feng, Zhendong ^{[1
,4
]}

Zhang, Na ^{[1
]}

Gao, Yu ^{[1
]}

Dong, Zhaocheng ^{[1
,3
]}

Zhou, Xiaoshan ^{[1
,3
]}

Du, Jieli ^{[1
,3
]}

Zhang, Naiqian ^{[1
,3
]}

Rui, Hongliang ^{[5
]}

Yuan, Li ^{[6
]}

Liu, Baoli ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China

[2] Beijing Tradit Chinese Med Hosp, Shunyi Branch, Beijing, Peoples R China

[3] Beijing Univ Chinese Med, Beijing, Peoples R China

[4] Pinggu Hosp, Beijing Chinese Med Hosp, Beijing, Peoples R China

[5] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing Inst Tradit Chinese Med, Beijing, Peoples R China

[6] Nantong Univ, Affiliated Hosp, Dept Nephrol, Nantong, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

idiopathic membranous nephropathy (IMN); helper T cells (Th cells); autoimmune; antibodies; germinal center (GC); DISEASE-ACTIVITY; B-CELLS; RECEPTOR; PATHOGENESIS; RATIO; IGG4; ABNORMALITY; RESPONSES; PROMOTE; SUBSETS;

D O I：

10.3389/fimmu.2021.665629

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the immune system produces an antibody response to its own antigens due to impaired immune tolerance. Although antibodies are derived from plasma cells differentiated by B cells, the T-B cells also contribute a lot to the immune system. In particular, the subsets of helper T (Th) cells, including the dominant subsets such as Th2, Th17, and follicular helper T (Tfh) cells and the inferior subsets such as regulatory T (Treg) cells, shape the immune imbalance of IMN and promote the incidence and development of autoimmune responses. After reviewing the physiological knowledge of various subpopulations of Th cells and combining the existing studies on Th cells in IMN, the role model of Th cells in IMN was explained in this review. Finally, the existing clinical treatment regimens for IMN were reviewed, and the importance of the therapy for Th cells was highlighted.

引用

页数：15

共 50 条

[21] Membranous nephropathy
Hoxha, Elion
Huber, Tobias B.
NEPHROLOGIE, 2025, 20 (01): : 12 - 17
[22] Therapy of tacrolimus combined with corticosteroids in idiopathic membranous nephropathy
Cui, W.
Lu, X.
Min, X.
Liu, M.
Guan, S.
Wang, Y.
Luo, M.
Li, W.
Li, Q.
Dong, W.
Miao, L.
Luo, P.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2017, 50 (04)
[23] Continuing the paradigm shift in the treatment of idiopathic membranous nephropathy
Barbari, Antoine
NATURE REVIEWS NEPHROLOGY, 2017, 13 (11) : 720 - 720
[24] Idiopathic membranous nephropathy with renal amyloidosis: A case report
Wang, Yue
Wang, Xueyao
Yu, Jinyu
Wu, Shan
Xu, Zhonggao
Sun, Weixia
FRONTIERS IN MEDICINE, 2022, 9
[25] Genetic Complexities of the HLA Region and Idiopathic Membranous Nephropathy
Mladkova, Nikol
Kiryluk, Krzysztof
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 28 (05): : 1331 - 1334
[26] Therapeutic targets in membranous nephropathy: plasma cells and complement
Tomas, Nicola M.
CLINICAL KIDNEY JOURNAL, 2024, 17 (09)
[27] Dissecting the relationships of IgG subclasses and complements in membranous lupus nephritis and idiopathic membranous nephropathy
Na, Woong
Yi, Kijong
Song, Young Soo
Park, Moon Hyang
PLOS ONE, 2017, 12 (03):
[28] T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases
Akiyama, Mitsuhiro
Alshehri, Waleed
Yoshimoto, Keiko
Kaneko, Yuko
ANNALS OF THE RHEUMATIC DISEASES, 2023, 82 (11) : 1371 - 1381
[29] Idiopathic membranous nephropathy and IgG4: an interesting relationship
Filippone, Edward J.
CLINICAL NEPHROLOGY, 2014, 82 (01) : 7 - 15
[30] Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension
Lu, Wanjun
Gong, Shuhao
Li, Juan
Wang, Ying
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2020, 19 (04) : 2615 - 2621

← 1 2 3 4 5 →