PARPs and ADP-ribosylation: 60 years on

被引：25

作者：

Kraus, W. Lee ^{[1
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Lab Signaling & Gene Regulat, Cecil H & Ida Green Ctr Reprod Biol Sci, Dallas, TX 75390 USA

来源：

GENES & DEVELOPMENT | 2020年 / 34卷 / 5-6期

基金：

美国国家卫生研究院;

关键词：

ADP-ribosylation; PARPs; posttranslational modification;

D O I：

10.1101/gad.336420.120

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Work on PARPs-a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of Genes & Development includes seven reviews that highlight these discoveries and point the way forward for future advances in the field.

引用

页码：251 / 253

页数：3

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