NF-κB signaling pathway as target for antiplatelet activity

In different nucleated cells, NF-kappa B has long been considered a prototypical proinflammatory signaling pathway with the expression of proinflammatory genes. Although platelets lack a nucleus, a number of functional transcription factors are involved in activated platelets, such as NF-kappa B. In platelet activation NF-kappa B regulation events include IKK beta phosphorylation, I kappa B alpha degradation, and p65 phosphorylation. Multiple pathways contribute to platelet activation and NF-kappa B is a common pathway in this activation. Therefore, in platelet activation the modulation of NF-kappa B pathway could be a potential new target in the treatment of inflammation-related vascular disease therapy (antiplatelet and antithrombotic activities). (C) 2016 Elsevier Ltd. All rights reserved.