Acid-sensing ion channel 2 (ASIC2) in the intestine of adult zebrafish

被引：15

作者：

Levanti, M. B. ^{[2
]}

Guerrera, M. C. ^{[2
]}

Calavia, M. G. ^{[1
]}

Ciriaco, E. ^{[2
]}

Montalbano, G. ^{[2
]}

Cobo, J. ^{[3
,4
]}

Germana, A. ^{[2
,5
]}

Vega, J. A. ^{[1
,6
]}

机构：

[1] Univ Oviedo, Dept Morfol & Biol Celular, Oviedo, Spain

[2] Univ Messina, Dipartimento Morfol Biochim Fisiol & Prod Anim, Sez Morfol, I-98100 Messina, Italy

[3] Univ Oviedo, Dept Cirugia & Especialidades Med Quirurg, Oviedo, Spain

[4] Inst Asturiano Odontol, Oviedo, Spain

[5] Univ Messina, CISS, I-98100 Messina, Italy

[6] Univ Oviedo, IUOPA, Oviedo, Spain

来源：

NEUROSCIENCE LETTERS | 2011年 / 494卷 / 01期

关键词：

Acid-sensing ion channels; Zebrafish; Enteric nervous system; Enteroendocrine cells; EXPRESSION; LOCALIZATION; NEURONS;

D O I：

10.1016/j.neulet.2011.02.046

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Acid-sensing ion channels (ASICs) in mammals monitor acid sensing and mechanoreception. They have a widespread expression in the central and peripheral nervous system, including the gut. The distribution of ASICs in zebrafish is known only in larvae and at the mRNA level. Here we have investigated the expression and cell distribution of ASIC2 in the gut of adult zebrafish using PCR, Western blot and immunohistochemistry. ASIC2 mRNA was detected in the gut, and a protein consistent with predicted ASIC2 (64 kDa molecular mass) was detected by Western blot. ASIC2 positivity was found in a subpopulation of myenteric neurons in the enteric nervous system, as well in enteroendocrine epithelial cells. These data demonstrate for the first time the occurrence of ASIC2 in the gut of adult zebrafish where it presumably acts as a chemosensor and a mechanosensor. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：24 / 28

页数：5

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