Exploring the mechnisms of molecular recognition by flavins

被引:8
作者
Singh, R [1 ]
Geetanjali
Babu, CR
机构
[1] Univ Delhi, Sch Environm Studies, Ctr Environm Management Degraded Ecosyst, Delhi 110007, India
[2] Univ Delhi, Dept Chem, Delhi 110007, India
关键词
D O I
10.1002/cbdv.200590023
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The design and development of chemical models for enzymes depends on the fundamental principles observed in biological systems. Molecular recognition of flavins by various receptors has attracted attention due to their applications as chemical models for flavoenzymes. The area of molecular recognition is being investigated through research at the interface of chemistry and biology. In this review, the literature has been surveyed to provide comprehensive coverage of the synthetic methodology of different flavins and receptors and their molecular-recognition studies. Various applications of flavin-receptor complexes have also been highlighted.
引用
收藏
页码:429 / 446
页数:18
相关论文
共 143 条
[1]   FLAVIN-6-CARBOXYLIC ACIDS AS NOVEL AND SIMPLE FLAVOENZYME MODELS - NONENZYMATIC STABILIZATION OF THE FLAVIN SEMIQUINONE RADICAL AND THE 4A-HYDROPEROXYFLAVIN BY INTRAMOLECULAR HYDROGEN-BONDING [J].
AKIYAMA, T ;
SIMENO, F ;
MURAKAMI, M ;
YONEDA, F .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (17) :6613-6620
[2]   ''Coulomb staircase'' at room temperature in a self-assembled molecular nanostructure [J].
Andres, RP ;
Bein, T ;
Dorogi, M ;
Feng, S ;
Henderson, JI ;
Kubiak, CP ;
Mahoney, W ;
Osifchin, RG ;
Reifenberger, R .
SCIENCE, 1996, 272 (5266) :1323-1325
[3]  
[Anonymous], 1963, ORG SYNTH
[4]   Quinoprotein-catalysed reactions [J].
Anthony, C .
BIOCHEMICAL JOURNAL, 1996, 320 :697-711
[5]   Molecular recognition at air-water and related interfaces: Complementary hydrogen bonding and multisite interaction [J].
Ariga, K ;
Kunitake, T .
ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (06) :371-378
[6]   Recognition of aqueous flavin mononucleotide on the surface of binary monolayers of guanidinium and melamine amphiphiles [J].
Ariga, K ;
Kamino, A ;
Koyano, H ;
Kunitake, T .
JOURNAL OF MATERIALS CHEMISTRY, 1997, 7 (07) :1155-1161
[7]  
AWASTHI A, 1994, INDIAN J HETEROCY CH, V4, P81
[8]   Molecular recognition of protein-ligand complexes: Applications to drug design [J].
Babine, RE ;
Bender, SL .
CHEMICAL REVIEWS, 1997, 97 (05) :1359-1472
[9]  
BEREZOVSKII V, 1961, ZH OBSHCH KHIM+, V31, P3827
[10]  
BLAKLEY RL, 1985, CHEM BIOCH PTERINS