MOBILIZATION OF HEMATOPOIETIC STEM CELLS WITH CYCLOPHOSPHAMIDE OR CYTARABINE IN COMBINATION WITH GRANULOCYTE COLONY-STIMULATING FACTOR IN PATIENTS WITH MULTIPLE MYELOMA, WHO ARE CANDIDATES FOR AUTOLOGOUS STEM CELL TRANSPLANTATION

被引：0

作者：

Babenetskaya, D., V ^{[1
]}

Motorin, D., V ^{[1
]}

Petrov, A., V ^{[1
]}

Alekseeva, Yu. A. ^{[1
]}

Zaritskey, A. Yu ^{[1
]}

机构：

[1] Fed Almazov North West Med Res Ctr, St Petersburg 197341, Russia

来源：

GEMATOLOGIYA I TRANSFUZIOLOGIYA | 2017年 / 62卷 / 04期

关键词：

hematopoietic stem cell mobilization; hematopoietic stem cell transplantation; multiple myeloma; PLUS G-CSF; MARROW TRANSPLANTATION; PLERIXAFOR; LYMPHOMA; BLOOD; MALIGNANCIES; STRATEGIES; GUIDELINES; THERAPIES; SURVIVAL;

D O I：

10.18821/0234-5730/2017-62-4-180-187

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In our research the comparison of different regimes of mobilization of HSC were carried out. First regime: conduct stimulation of granulopoiesis using granulocyte colony-stimulating factor (GCSF). Other regimes: of mobilization with chemotherapy (cyclophosphamide or cytarabine). The efficiency and the toxicity were assessed. The grafts with satisfactory cellularity were obtained in 91% patients. The number of CD34(+)cell/ml were obtained in the first apheresis and from whole mobilization in patients with complete remission (CR) were more than the number of in patients with < CR. CD34(+) cell number in the blood correlate well with total number of CD34(+) yielded from apheresis in same day. The number of CD34(+) cells/microliter yielded from mobilization was more in group with chemomobilization than in group with GCSF only. In comparison two groups of chemomobilization: the number of CD34(+) in peripheral blood in day apheresis was more in group with AraC-GCSF; p = 0.173. There was revealed lesser toxicity in group with AraC-GCSF.

引用

页码：180 / 187

页数：8

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