Monoclonal gammopathy of undetermined significance and multiple myeloma

被引：2
|
作者：
Schmalzing, M. [1 ]
Tony, H. -P. [1 ]
Knop, S. [1 ]
机构：
[1] Univ Klinikum Wurzburg, Med Klin & Poliklin 2, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany
来源：
ZEITSCHRIFT FUR RHEUMATOLOGIE | 2017年 / 76卷
关键词：
RHEUMATOID-ARTHRITIS; PSORIATIC PATIENTS; THERAPY; DEXAMETHASONE; RISK;
D O I：
10.1007/s00393-017-0335-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In rheumatological practice monoclonal gammopathy of undetermined significance (MGUS) is a common incidental finding. Several rheumatic inflammatory diseases are known to have an elevated risk of MGUS, which can evolve into multiple myeloma or other lymphatic malignancies. The relevant definitions of disease entities are described, as well as algorithms for further diagnostic work-up and follow-up for monoclonal gammopathy, depending on the risk of progression. Therapeutic strategies against multiple myeloma are presented. Some of these therapeutic modalities could play a future role in treating plasma cell-dominated autoimmune diseases.
引用
收藏
页码：33 / 37
页数：5
相关论文
共 50 条
  • [41] PHENOTYPE OF PLASMA CELLS IN MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE AND MULTIPLE MYELOMA SUBJECTS
    Kovarova, L.
    Buresova, I.
    Suska, R.
    Pour, L.
    Zahradova, L.
    Sandecka, V.
    Penka, M.
    Hajek, R.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 82 - 82
  • [42] Management of Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple Myeloma (SMM)
    Kyle, Robert A.
    Buadi, Francis
    Rajkumar, S. Vincent
    ONCOLOGY-NEW YORK, 2011, 25 (07): : 578 - 586
  • [43] Monosomy 13 is associated with the transition of monoclonal gammopathy of undetermined significance to multiple myeloma
    Avet-Loiseau, H
    Li, JY
    Morineau, N
    Facon, T
    Brigaudeau, C
    Harousseau, JL
    Grosbois, B
    Bataille, R
    BLOOD, 1999, 94 (08) : 2583 - 2589
  • [44] Identification of genes associated with multiple myeloma and monoclonal gammopathy of undetermined significance using the myeloma microarray
    Gaiger, A
    Fonseca, R
    Jelinek, D
    Ordonez, N
    Pyle, R
    Molesh, D
    Persing, D
    Jaeger, U
    Jeffery, E
    Greipp, P
    EUROPEAN JOURNAL OF CANCER, 2002, 38 : S103 - S103
  • [45] Laboratory testing for monoclonal gammopathies: Focus on monoclonal gammopathy of undetermined significance and smoldering multiple myeloma
    Willrich, Maria A. V.
    Murray, David L.
    Kyle, Robert A.
    CLINICAL BIOCHEMISTRY, 2018, 51 : 38 - 47
  • [46] Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance
    Vachon, Celine M.
    Kyle, Robert A.
    Therneau, Terry M.
    Foreman, Barbara J.
    Larson, Dirk R.
    Colby, Colin L.
    Phelps, Tara K.
    Dispenzieri, Angela
    Kumar, Shaji K.
    Katzmann, Jerry A.
    Rajkumar, S. Vincent
    BLOOD, 2009, 114 (04) : 785 - 790
  • [47] Increased Risk of Monoclonal Gammopathy in First-Degree Relatives of Patients with Multiple Myeloma or Monoclonal Gammopathy of Undetermined Significance
    Vachon, Celine M.
    Kyle, Robert
    Therneau, Terry
    Larson, Dirk R.
    Colby, Colin
    Foreman, Barbara J.
    Dispenzieri, Angela
    Kumar, Shaji
    Katzmann, Jerry
    Rajkumar, S. Vincent
    BLOOD, 2008, 112 (11) : 591 - 591
  • [48] Multiple myeloma disguised as monoclonal gammopathy of undetermined significance? MGUS-like phenotype of a multiple myeloma subgroup
    Hammami, Emna
    HEMATOLOGIE, 2023, 29 (04): : 218 - 219
  • [49] The relationship between proliferation and apoptosis in patients with monoclonal gammopathy of undetermined significance or multiple myeloma
    Scudla, Vlastimil
    Ordeltova, Marta
    Bacovsky, Jaroslav
    Vytrasova, Marketa
    Horak, Pavel
    Minarik, Jiri
    HAEMATOLOGICA, 2005, 90 (12) : 1713 - 1714
  • [50] IGG SUBCLASS DISTRIBUTION IN PATIENTS WITH MULTIPLE-MYELOMA OR WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
    PAPADEA, C
    REIMER, CB
    CHECK, IJ
    ANNALS OF CLINICAL AND LABORATORY SCIENCE, 1989, 19 (01): : 27 - 37
12345