Adolescent nicotine treatment causes robust locomotor sensitization during adolescence but impedes the spontaneous acquisition of nicotine intake in adult female Wistar rats

被引:9
作者
Chellian, Ranjithkumar [1 ]
Behnood-Rod, Azin [1 ]
Wilson, Ryann [1 ]
Febo, Marcelo [1 ]
Bruijnzeel, Adriaan W. [1 ,2 ]
机构
[1] Univ Florida, Dept Psychiat, 1149 Newell Dr, Gainesville, FL 32611 USA
[2] Univ Florida, Dept Neurosci, Gainesville, FL 32610 USA
关键词
Adolescent; Nicotine; Sensitization; Acquisition; Self-administration; Sex; Rats; ANXIETY-LIKE BEHAVIOR; ELEVATED PLUS-MAZE; REPEATED INTRAVENOUS NICOTINE; SEX-DIFFERENCES; EXPOSURE; AMPHETAMINE; DOPAMINE; VULNERABILITY; PREEXPOSURE; ADDICTION;
D O I
10.1016/j.pbb.2021.173224
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Very few people are able to quit smoking, and therefore it is essential to know which factors contribute to the development of compulsive nicotine use. These studies aimed to investigate if early-adolescent nicotine exposure causes locomotor sensitization and affects anxiety-like behavior and the spontaneous acquisition of intravenous nicotine self-administration. Early-adolescent male and female rats were treated with nicotine from postnatal (P) days 24 to 42, and anxiety-like behavior and locomotor activity were investigated one day after the cessation of nicotine treatment and in adulthood (>P75). The spontaneous acquisition of nicotine self-administration was also investigated in adulthood. The rats self-administered 0.03 mg/kg/infusion of nicotine for six days under a fixed-ratio (FR) 1 schedule and four days under an FR2 schedule (3-h sessions). Repeated nicotine administration increased locomotor activity, rearing, and stereotypies in a small open field in adolescent male and female rats. One day after the last nicotine injection, the percentage of open arm entries in the elevated plus-maze test was decreased in the males and increased in the females. However, locomotor activity in the small open field was unaffected. Adolescent nicotine treatment did not affect anxiety-like behavior and locomotor activity in adulthood. During the 10-day nicotine self-administration period, the females had a higher level of nicotine intake than the males. Adolescent nicotine treatment decreased nicotine intake in the females. In conclusion, these findings indicate that repeated nicotine administration during adolescence causes robust behavioral sensitization and leads to lower nicotine intake in females throughout the acquisition period in adulthood in rats.
引用
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页数:13
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共 79 条
[1]   Early adolescent nicotine exposure affects later-life cocaine reward in mice [J].
Alajaji, Mai ;
Lazenka, Matthew F. ;
Kota, Dena ;
Wise, Laura E. ;
Younis, Rabha M. ;
Carroll, F. Ivy ;
Levine, Amir ;
Selley, Dana E. ;
Sim-Selley, Laura J. ;
Damaj, M. Imad .
NEUROPHARMACOLOGY, 2016, 105 :308-317
[2]   Onset of Regular Smoking Before Age 21 and Subsequent Nicotine Dependence and Cessation Behavior Among US Adult Smokers [J].
Ali, Fatma Romeh M. ;
Agaku, Israel T. ;
Sharapova, Saida R. ;
Reimels, Elizabeth A. ;
Homa, David M. .
PREVENTING CHRONIC DISEASE, 2020, 17
[3]  
American Psychiatric Association [APA], 2013, Diagnostic and Statistical Manual of Mental Disorders (DSM-5 (R)), V5, DOI [DOI 10.1176/APPI.BOOKS.9780890425596, 10.1176/appi.books.9780890420249.dsm-iv-tr]
[4]   Early adolescents show enhanced acute cocaine-induced locomotor activity in comparison to late adolescent and adult rats [J].
Badanich, Kimberly A. ;
Maldonado, Antoniette M. ;
Kirstein, Cheryl L. .
DEVELOPMENTAL PSYCHOBIOLOGY, 2008, 50 (02) :127-133
[5]   Transitions from first substance use to substance use disorders in adolescence: Is early onset associated with a rapid escalation? [J].
Behrendt, S. ;
Wittchen, H. -U. ;
Hoefler, M. ;
Lieb, R. ;
Beesdo, K. .
DRUG AND ALCOHOL DEPENDENCE, 2009, 99 (1-3) :68-78
[6]   Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics [J].
Benowitz, Neal L. .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2009, 49 :57-71
[7]   Behavioral sensitization following repeated intravenous nicotine administration: Gender differences and gonadal hormones [J].
Booze, RM ;
Welch, MA ;
Wood, ML ;
Billings, KA ;
Apple, SR ;
Mactutus, CF .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1999, 64 (04) :827-839
[8]   Immediate and long-term behavioral effects of a single nicotine injection in adolescent and adult rats [J].
Brielmaier, Jennifer M. ;
McDonald, Craig G. ;
Smith, Robert F. .
NEUROTOXICOLOGY AND TERATOLOGY, 2007, 29 (01) :74-80
[9]   Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats [J].
Bruijnzeel, Adriaan W. ;
Qi, Xiaoli ;
Guzhva, Lidia V. ;
Wall, Shannon ;
Deng, Jie V. ;
Gold, Mark S. ;
Febo, Marcelo ;
Setlow, Barry .
PLOS ONE, 2016, 11 (04)
[10]   Tobacco addiction and the dysregulation of brain stress systems [J].
Bruijnzeel, Adrie W. .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2012, 36 (05) :1418-1441