Impact of dietary propionate on fructose-induced changes in lipid metabolism, gut microbiota and short-chain fatty acids in mice

被引:10
作者
Bruetting, Christine [1 ]
Lara Bisch, Milena [1 ]
Brandsch, Corinna [1 ]
Hirche, Frank [1 ]
Stangl, Gabriele I. [1 ]
机构
[1] Martin Luther Univ Halle Wittenberg, Inst Agr & Nutr Sci, Halle, Germany
关键词
Dietary fructose; dietary propionate; lipids; short-chain fatty acids; gut microbiota; LIVER-DISEASE; GLUCOSE-METABOLISM; MASS-SPECTROMETRY; INDUCED OBESITY; FEMALE MICE; CHOLESTEROL; STEATOSIS; QUANTIFICATION; CHROMATOGRAPHY; LIPOGENESIS;
D O I
10.1080/09637486.2020.1773415
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Propionate has antimicrobial activity and is suggested to influence lipid metabolism. Here, we investigated the effect of propionate on lipid metabolism and the gut microbiome in fructose-fed mice as a model of diet-induced steatosis and gut dysbiosis. Therefore, 48 male wild-type mice were fed isoenergetic diets with either 0% fructose (F-) or 40% fructose (F+) that contained 0% propionate (P-) or 1% propionate (P+) for 7 weeks. Mice that received the F+ diets developed fatty livers, had fewer small intestinal proteobacteria and colonic actinobacteria and were characterised by changes in bacterial genera (e.g.,Allobaculum,Lachnospiraceae, andEscherichia). Interestingly, mice fed the F+ diets had higher levels of propionate and butyrate in the circulation than mice fed the F- diets (p < 0.05). Treatment with propionate influenced neither hepatic or plasma lipids nor levels of circulating SCFAs. With the exception ofVerrucomicrobia, other bacterial phyla were not affected by propionate.
引用
收藏
页码:160 / 173
页数:14
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