Attenuation of anti-ischemic efficacy during chronic therapy with nicorandil in patients with stable angina pectoris

被引：23

作者：

Rajaratnam, R ^{[1
]}

Brieger, DB ^{[1
]}

Hawkins, R ^{[1
]}

Freedman, SB ^{[1
]}

机构：

[1] Univ Sydney, Concord Repatriat Gen Hosp, Dept Cardiol, Sydney, NSW 2139, Australia

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1999年 / 83卷 / 07期

关键词：

D O I：

10.1016/S0002-9149(99)00025-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

After 2 weeks of nicorandil therapy, time to ischemia on stress testing was significantly less than on day 1 and not different from placebo. These data are consistent with attentuation of the anti-ischemic effects of this drug and suggest that the potassium channel-opening properties do not compensate for development of attenuation to the nitrate component of nicorandil.

引用

页码：1120 / +

页数：6

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