Autologous bone marrow-derived mononuclear cell therapy in three patients with severe asthma

被引:17
作者
Aguiar, Fabio S. [1 ]
Melo, Andre S. [1 ]
Araujo, Ana Maria S. [1 ]
Cardoso, Alexandre P. [1 ]
de Souza, Sergio Augusto L. [2 ]
Lopes-Pacheco, Miqueias [3 ,4 ,5 ]
Cruz, Fernanda F. [3 ,4 ]
Xisto, Debora G. [3 ,4 ]
Asensi, Karina D. [4 ,6 ]
Faccioli, Lanuza [4 ,6 ]
Salgado, Anna Beatriz S. [7 ]
Landesmann, Maria Carolina P. P. [2 ]
Goldenberg, Regina C. S. [4 ,6 ]
Gutfilen, Bianca [2 ]
Morales, Marcelo M. [4 ,5 ]
Rocco, Patricia R. M. [3 ,4 ]
Silva, Jose R. [1 ]
机构
[1] Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Inst Thorac Med, Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Dept Radiol, Rio De Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Investigat, Rio De Janeiro, Brazil
[4] Natl Inst Sci & Technol Regenerat Med, Rio De Janeiro, Brazil
[5] Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Cellular & Mol Physiol, Rio De Janeiro, Brazil
[6] Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Cellular & Mol Cardiol, Rio De Janeiro, Brazil
[7] Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Dept Clin Hematol, Rio De Janeiro, Brazil
关键词
Asthma; Bone marrow mononuclear cells; Cell therapy; Autologous transplantation; Lung; MESENCHYMAL STROMAL CELLS; MURINE MODEL; SAFETY; EXERT;
D O I
10.1186/s13287-020-01675-x
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Background Despite recent advances in understanding its pathophysiology and development of novel therapies, asthma remains a serious public health issue worldwide. Combination therapy with inhaled corticosteroids and long-acting beta(2)-adrenoceptor agonists results in disease control for many patients, but those who exhibit severe asthma are often unresponsive to conventional treatment, experiencing worse quality of life, frequent exacerbations, and increasing healthcare costs. Bone marrow-derived mononuclear cell (BMMC) transplantation has been shown to reduce airway inflammation and remodeling and improve lung function in experimental models of allergic asthma. Methods This is a case series of three patients who presented severe asthma, unresponsive to conventional therapy and omalizumab. They received a single intravenous dose of autologous BMMCs (2 x 10(7)) and were periodically evaluated for 1 year after the procedure. Endpoint assessments included physical examination, quality of life questionnaires, imaging (computed tomography, single-photon emission computed tomography, and ventilation/perfusion scan), lung function tests, and a 6-min walk test. Results All patients completed the follow-up protocol. No serious adverse events attributable to BMMC transplantation were observed during or after the procedure. Lung function remained stable throughout. A slight increase in ventilation of the right lung was observed on day 120 after BMMC transplantation in one patient. All three patients reported improvement in quality of life in the early post-procedure course. Conclusions This paper described for the first time the effects of BMMC therapy in patients with severe asthma, providing a basis for subsequent trials to assess the efficacy of this therapy.
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页数:9
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