Live or Let Die: T Cell Survival in Cancer Immunotherapy

被引：1
作者：
Ruotsalainen, Janne [1 ]
Tueting, Thomas [1 ]
机构：
[1] Otto von Guericke Univ, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany
来源：
IMMUNITY | 2019年 / 50卷 / 02期
关键词：
RESPONSES;
D O I：
10.1016/j.immuni.2019.01.016
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Combination immune checkpoint blockade targeting CTLA-4 and PD-1 is thought to reinvigorate exhausted T cells better than monotherapies. In this issue of Immunity, Pai et al. (2019) show that, in the setting of low tumor burden, this combination regimen promotes interferon-gamma-dependent T cell hyperactivation and death and thus favors tumor progression.
引用
收藏
页码：280 / 282
页数：4
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