Antiplasmodial phenolic compounds from Piptadenia pervillei

被引：33

作者：

Ramanandralbe, Voahangy

Grellier, Philippe ^{[3
]}

Martin, Marie-Therese ^{[2
]}

Deville, Alexandre ^{[1
]}

Joyeau, Roger ^{[1
]}

Ramanitrahasimbola, David

Mouray, Elisabeth ^{[3
]}

Rasoanaivo, Philippe

Mambu, Lengo ^{[1
]}

机构：

[1] Museum Natl Hist Nat, CNRS Chim & Biochim Subst Nat, USM 0502,UMR 5154, Dept Regulat Dev & Divers Mol, F-75231 Paris 05, France

[2] CNRS, Inst Chim Subst Nat, Gif Sur Yvette, France

[3] Museum Natl Hist Nat, USM Biol Fonct Protozoaires 0504, Dept Regulat Dev & Diversite Mol, F-75231 Paris, France

来源：

PLANTA MEDICA | 2008年 / 74卷 / 04期

关键词：

Piptadenia pervillei; Fabaceae; antiplasmodial activity; (+)-catechin gallate;

D O I：

10.1055/s-2008-1034328

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Piptadenia pervillei Vatke (Fabaceae) was selected from a screening programme devoted to the search of naturally-occuring antimalarial compounds from plants of Madagascar. Bioassay-guided fractionation of the ethyl acetate extract of the leaves led to the isolation of four phenolic compounds, (+)-catechin (1), (+)-catechin 5-gallate (2), (+)-catechin 3-gallate (3) and ethyl gallate (4). Structures were determined by NMR and mass spectroscopy. Compounds 2 and 3 displayed the highest in vitro activity against the chloroquine-resistant strain FcB1 of Plasmodium falciparum with IC50 values of 1.2 mu M and 1.0 mu M, respectively, and no significant cytotoxicity against the human embryonic lung cells MRC-5 was measured (IC50 values > 75 mu M). Five analogues (5-9) of (+)-catechin 5-gallate (2) were synthesized and evaluated for their antiplasmodial activity.

引用

页码：417 / 421

页数：5

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