Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells

被引：202
作者：
Gimble, Jeffrey M. [1 ,2 ]
Guilak, Farshid [3 ]
Bunnell, Bruce A. [4 ,5 ]
机构：
[1] Louisiana State Univ Syst, Stem Cell Biol Lab, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA
[2] Louisiana State Univ, Hlth Sci Ctr, Dept Orthoped, New Orleans, LA 70112 USA
[3] Duke Univ, Med Ctr, Div Orthopaed Surg, Dept Surg, Durham, NC 27710 USA
[4] Tulane Univ, Hlth Sci Ctr, Tulane Ctr Gene Therapy, New Orleans, LA 70112 USA
[5] Tulane Natl Primate Res Ctr, Covington, LA 70433 USA
来源：
STEM CELL RESEARCH & THERAPY | 2010年 / 1卷
关键词：
MESENCHYMAL STEM-CELLS; FIBROBLAST-GROWTH-FACTOR; COMPLEX PERIANAL FISTULA; DE-NOVO ADIPOGENESIS; ADULT STROMAL CELLS; IN-VIVO; BONE-MARROW; ASSISTED LIPOTRANSFER; CROHNS-DISEASE; POSTNATAL NEOVASCULARIZATION;
D O I：
10.1186/scrt19
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of adult stem cells suitable for tissue engineering and regenerative medicine applications. The past decade has witnessed an explosion of preclinical data relating to the isolation, characterization, cryopreservation, differentiation, and transplantation of freshly isolated stromal vascular fraction cells and adherent, culture-expanded, adipose-derived stromal/stem cells in vitro and in animal models. This body of work has provided evidence supporting clinical translational applications of adipose-derived cells in safety and efficacy trials. The present article reviews the case reports and phase I-III clinical evidence using autologous adipose-derived cells that have been published, to date, in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines. Future directions and challenges facing the field are discussed and evaluated.
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页数：8
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