Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells

被引：0

作者：

Ho, Tsung-Jung ^{[1
,2
,3
]}

Goswami, Debakshee ^{[4
]}

Kuo, Wei-Wen ^{[5
]}

Kuo, Chia-Hua ^{[6
]}

Yen, Shih Cheng ^{[7
]}

Lin, Pi-Yu ^{[7
]}

Lin, Shinn-Zong ^{[8
,9
]}

Hsieh, Dennis Jine-Yuan ^{[10
]}

Shibu, Marthandam Asokan ^{[11
]}

Huang, Chih-Yang ^{[4
,12
,13
,14
,15
]}

机构：

[1] Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Dept Chinese Med, Hualien 970, Taiwan

[2] Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Integrat Ctr Tradit Chinese & Modern Med, Hualien 970, Taiwan

[3] Tzu Chi Univ, Buddhist Tzu Chi Med Fdn, Coll Med, Sch Postbaccalaureate Chinese Med, Hualien 970, Taiwan

[4] Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Cardiovasc & Mitochondrial Related Dis Res Ctr, Hualien 970, Taiwan

[5] China Med Univ, Dept Biol Sci & Technol, Taichung 404, Taiwan

[6] Univ Taipei, Dept Sports Sci, Taipei 111, Taiwan

[7] Buddhist Compass Relief Tzu Chi Fdn, Hualien 970, Taiwan

[8] Buddhist Tzu Chi Med Fdn, Bioinnovat Ctr, Hualien 970, Taiwan

[9] Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Dept Neurosurg, Hualien 970, Taiwan

[10] Chung Shan Med Univ, Dept Med Lab & Biotechnol, Taichung 40201, Taiwan

[11] Bharathiar Univ, Dept Biotechnol, Coimbatore 641046, Tamil Nadu, India

[12] China Med Univ, Grad Inst Biomed Sci, Taichung 404, Taiwan

[13] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[14] Asia Univ, Dept Biotechnol, Taichung 41354, Taiwan

[15] Tzu Chi Univ Sci & Technol, Buddhist Tzu Chi Med Fdn, Ctr Gen Educ, Hualien 970, Taiwan

来源：

AGING-US | 2022年 / 14卷 / 15期

关键词：

anti-aging; Artemisia argyi; antioxidant; klotho; stem cell; DOUBLE-STRAND BREAKS; DNA-DAMAGE-RESPONSE; CELLULAR SENESCENCE; OXIDATIVE STRESS; LIFE-SPAN; TELOMERASE; MEMORY; MICE; MECHANISM;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is accompanied by functional loss of many cellular pathways, creating an increased risk of many age-related complications (ARC). Aging causes stem cell exhaustion with a concomitant increase in cellular dysfunction. Recently, interest in senotherapeutics has been growing rapidly to promote healthy aging and as an intervention for ARCs. This research focused on screening the senomorphic properties of Artemisia argyi, as an emerging strategy for longevity, and prevention or treatment of ARCs. In this study, we aimed to find the clinical efficacy of daily consumption of Artemisia argyi water extract (AAW) on aging. In vitro 0.1 mu M Doxorubicin induced senescent human adipose derived mesenchymal stem cells was treated with different concentrations of AAW to show its anti-aging effect. 15 months old SHR rats (n=6) were treated with 7.9 mg/ml AAW for 4 weeks and anti-aging effect was evaluated. In vitro study showed the protective effect of AAW in telomere shortening and helps in maintaining a balance in the expression of anti-aging protein Klotho and TERT. AAW effectively reduced mitochondria! superoxide and also provided a protective shield against senescence markers like over-expression of p21 and formation of double strand breaks, which is known to cause premature aging. Moreover, animal studies indicated that AAW promoted the expression of Klotho in naturally aging rats. In addition, AAW successfully restored the decline cardiac function and improved the grip strength and memory of aging rat. These findings showed that therapeutic targeting of senescent stem cells by AAW restored stem cell homeostasis and improves overall health.

引用

页码：6187 / 6201

页数：15

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