Dedifferentiated Melanoma: A Diagnostic Histological Pitfall-Review of the Literature with Case Presentation

被引：12
作者：
Cazzato, Gerardo [1 ]
Lospalluti, Lucia [2 ]
Colagrande, Anna [1 ]
Cimmino, Antonietta [1 ]
Romita, Paolo [2 ]
Foti, Caterina [2 ]
Demarco, Aurora [2 ]
Arezzo, Francesca [3 ]
Loizzi, Vera [3 ]
Cormio, Gennaro [3 ]
Sablone, Sara [4 ]
Resta, Leonardo [1 ]
Rossi, Roberta [1 ]
Ingravallo, Giuseppe [1 ]
机构：
[1] Univ Bari Aldo Moro, Sect Pathol, Dept Emergency & Organ Transplantat DETO, I-70124 Bari, Italy
[2] Univ Bari Aldo Moro, Sect Dermatol, Dept Biomed Sci & Human Oncol DIMO, I-70124 Bari, Italy
[3] Univ Bari Aldo Moro, Sect Ginecol & Obstet, Dept Biomed Sci & Human Oncol DIMO, I-70124 Bari, Italy
[4] Univ Bari, Bari Policlin Hosp, Sect Legal Med, Dept Interdisciplinary Med, I-70124 Bari, Italy
来源：
DERMATOPATHOLOGY | 2021年 / 8卷 / 04期
关键词：
dedifferentiated melanoma; malignant melanoma (MM); immunohistochemistry; pitfall; diagnosis; TRANSCRIPTION FACTOR; MALIGNANT-MELANOMA; METASTATIC MELANOMA; PLASTICITY; TUMOR; MITF;
D O I：
10.3390/dermatopathology8040051
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Dedifferentiated melanoma is a particular form of malignant melanoma with a progressive worsening of the patient's clinical outcome. It is well known that melanoma can assume different histo-morphological patterns, to which specific genetic signatures correspond, sometimes but not always. In this review we address the diagnostic difficulties in correctly recognizing this entity, discuss the major differential diagnoses of interest to the dermatopathologist, and conduct a review of the literature with particular attention and emphasis on the latest molecular discoveries regarding the dedifferentiation/undifferentiation mechanism and more advanced therapeutic approaches.
引用
收藏
页码：494 / 501
页数：8
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