Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model

被引：87

作者：

Yamamoto, Mako ^{[1
,2
]}

Zhao, Ming ^{[1
]}

Hiroshima, Yukihiko ^{[1
,2
]}

Zhang, Yong ^{[1
]}

Shurell, Elizabeth ^{[4
]}

Eilber, Fritz C. ^{[4
]}

Bouvet, Michael ^{[2
]}

Noda, Makoto ^{[3
]}

Hoffman, Robert M. ^{[1
,2
]}

机构：

[1] AntiCancer Inc, Ostrow St, San Diego, CA 92111 USA

[2] Univ Calif San Diego, Dept Surg, West Arbor Dr, San Diego, CA 92103 USA

[3] Kyoto Univ, Grad Sch Med, Dept Mol Oncol, Sakyo Ku, Yoshida Konoe Cho, Kyoto, Japan

[4] Univ Calif Los Angeles, Div Surg Oncol, Los Angeles, CA USA

来源：

PLOS ONE | 2016年 / 11卷 / 08期

关键词：

SOFT-TISSUE SARCOMA; HUMAN PANCREATIC-CANCER; HUMAN OVARIAN-CANCER; TYPHIMURIUM A1-R; BREAST-CANCER; ATTENUATED SALMONELLA; METASTATIC MELANOMA; LUNG METASTASIS; ENGINEERED SALMONELLA; IMMUNOCOMPETENT MICE;

D O I：

10.1371/journal.pone.0160882

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tumor-targeting Salmonella enterica serovar Typhimurium A1-R (Salmonella A1-R) had strong efficacy on a melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. GFP-expressing Salmonella A1-R highly and selectively colonized the PDOX melanoma and significantly suppressed tumor growth (p = 0.021). The combination of Salmonella A1-R and cisplatinum (CDDP), both at low-dose, also significantly suppressed the growth of the melanoma PDOX (P = 0.001). Salmonella A1-R has future clinical potential for combination chemotherapy with CDDP of melanoma, a highly-recalcitrant cancer.

引用

页数：12

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