Modular organizations of novel cetacean papillomaviruses

被引:47
作者
Gottschling, Marc [1 ]
Bravo, Ignacio G. [2 ]
Schulz, Eric [3 ]
Bracho, Maria A. [2 ]
Deaville, Rob [4 ]
Jepson, Paul D. [4 ]
Van Bressem, Marie-Francoise [5 ]
Stockfleth, Eggert [3 ]
Nindl, Ingo [3 ]
机构
[1] Univ Munich, Dept Biol Systemat Bot & Mycol 1, GeoBioctr, D-80638 Munich, Germany
[2] Ctr Publ Hlth Res CSISP, Valencia, Spain
[3] Charite, HTCC, Clin Dermatol Venerol & Allergol, D-13353 Berlin, Germany
[4] Zool Soc London, Inst Zool, London NW1 4RY, England
[5] Museo Delfines, CEPEC, Cetacean Conservat Med Grp CMED, Pucusana, Peru
关键词
Co-divergence; Evolutionary virology; Genital wart; Host; Pathogen; Sexually transmitted infection; SEXUALLY-TRANSMITTED-DISEASES; GENOMIC CHARACTERIZATION; PHYLOGENETIC ANALYSIS; TYPE-1; SEQUENCE; PORPOISES; CLONING; GENES; DNA; CLASSIFICATION;
D O I
10.1016/j.ympev.2010.12.013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The phylogenetic position of cetacean papillomaviruses (PVs: Omikron-PVs and Upsilon-PVs) varies depending on the region of the genome analysed. They cluster together with Alpha-PVs when analysing early genes and with Xi-PVs and Phi-PVs when analysing late genes. We cloned and sequenced the complete genomes of five novel PVs, sampled from genital and oesophageal lesions of free-ranging cetaceans: Delphinus delphis (DdPV1), Lagenorhynchus acutus (TtPV3 variant), and Phocoena phocoena (PphPV1, PphPV2, and PphPV3). Using Maximum Likelihood and Bayesian approaches, all cetacean PVs constituted a monophyletic group with Alpha-, Omega-, and Dyodelta-PVs as inferred from E1-E2 early genes analyses, thus matching the shared phenotype of mucosal tropism. However, cetacean PVs, with the exception of PphPV3, were the closest relatives of Xi-PVs and Phi-PVs in L2-L1 late genes analyses, isolated from cow and goat, thus reflecting the close relationship between Cetacea and Artiodactyla. Our results are compatible with a recombination between ancestral PVs infecting the Cetartiodactyla lineage. Our study supports a complex evolutionary scenario with multiple driving forces for PV diversification, possibly including recombination and also interspecies transmission. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:34 / 42
页数:9
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