Comprehensive Analysis of Prognostic Microenvironment-Related Genes in Invasive Breast Cancer

被引：5

作者：

Shi, Yingrong ^{[1
]}

Chen, Si ^{[1
]}

Xing, Huijuan ^{[1
]}

Jiang, Guanglie ^{[1
]}

Wu, Nan ^{[1
]}

Liu, Qiannan ^{[1
]}

Sakamoto, Norihiro ^{[2
]}

Kuno, Takayoshi ^{[1
,2
]}

Sugiura, Reiko ^{[3
]}

Xiao, Qinghuan ^{[4
]}

Jin, Feng ^{[5
]}

Fang, Yue ^{[1
]}

Yao, Fan ^{[5
]}

机构：

[1] China Med Univ, Sch Pharm, Dept Microbial & Biochem Pharm, Shenyang, Peoples R China

[2] Kobe Univ, Grad Sch Med, Div Food & Drug Evaluat Sci, Kobe, Japan

[3] Kinki Univ, Sch Pharmaceut Sci, Lab Mol Pharmacogen, Higashiosaka, Osaka, Japan

[4] China Med Univ, Sch Pharm, Dept Ion Channel Pharmacol, Shenyang, Peoples R China

[5] China Med Univ, Affiliated Hosp 1, Res Unit Gen Surg, Dept Breast Surg & Surg Oncol, Shenyang, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 11卷

基金：

中国国家自然科学基金;

关键词：

invasive breast cancer; TCGA database; prognosis; SASH3; immune; stromal; ESTIMATE score; tumor microenvironment; SUPPRESSOR SASH1 INTERACTS; DOWN-REGULATION; EXPRESSION; ASSOCIATION; LYMPHOCYTES; METASTASIS; ACTIVATION; CHEMOKINES; RECEPTORS; GROWTH;

D O I：

10.3389/fonc.2021.576911

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies reveal that tumor microenvironment contributes to breast cancer (BRCA) development, progression, and therapeutic response. However, the contribution of the tumor microenvironment-related genes in routine diagnostic testing or therapeutic decision making for BRCA remains elusive. Immune/stromal/ESTIMATE scores calculated by the ESTIMATE algorithm quantify immune and stromal components in a tumor, and thus can reflect tumor microenvironment. To investigate the association of the tumor microenvironment-related genes with invasive BRCA prognosis, here we analyzed the immune/stromal/ESTIMATE scores in combination with The Cancer Genome Atlas (TCGA) database in invasive BRCA. We found that immune/stromal/ESTIMATE scores were significantly correlated with the invasive BRCA clinicopathological factors. Based on the immune/stromal/ESTIMATE scores, we extracted a series of differential expression genes (DEGs) related to the tumor microenvironment. Survival analysis was further performed to identify a list of high-frequency DEGs (HF-DEGs), which exhibited prognostic value in invasive BRCA. Importantly, consistent with the results of bioinformatics analysis, immunohistochemistry results showed that high SASH3 expression was associated with a good prognosis in invasive BRCA patients. Our findings suggest that the tumor microenvironment-related HF-DEGs identified in this study have prognostic values and may serve as potential biomarkers and therapeutic targets for invasive BRCA.

引用

页数：13

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