The Adenosine Pathway and Human Immunodeficiency Virus-Associated Inflammation

被引：9

作者：

Hixson, Emily A. ^{[1
]}

Borker, Priya, V ^{[2
]}

Jackson, Edwin K. ^{[3
]}

Macatangay, Bernard J. ^{[1
,4
]}

机构：

[1] Univ Pittsburgh, Dept Infect Dis & Microbiol, Grad Sch Publ Hlth, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Sch Med, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Div Infect Dis, Sch Med, Pittsburgh, PA 15213 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 09期

关键词：

adenosine; HIV; inflammation; non-AIDS comorbidities; purinergic signaling; REGULATORY T-CELLS; HIV-INFECTED SUBJECTS; IMMUNE ACTIVATION; MICROBIAL TRANSLOCATION; VASCULAR INFLAMMATION; P2X(7) RECEPTOR; DOWN-REGULATION; TISSUE-DAMAGE; EXPRESSION; ATP;

D O I：

10.1093/ofid/ofab396

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus (HIV) is associated with an increased risk of age-associated comorbidities and mortality compared to people without HIV. This has been attributed to HIV-associated chronic inflammation and immune activation despite viral suppression. The adenosine pathway is an established mechanism by which the body regulates persistent inflammation to limit tissue damage associated with inflammatory conditions. However, HIV infection is associated with derangements in the adenosine pathway that limits its ability to control HIV-associated inflammation. This article reviews the function of purinergic signaling and the role of the adenosine signaling pathway in HIV-associated chronic inflammation. This review also discusses the beneficial and potential detrimental effects of pharmacotherapeutic strategies targeting this pathway among people with HIV.

引用

页数：10

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