Catalyst-free, one-pot strategy to access 3-substituted-5-amino-1,2,4-thiadiazoles in water

被引：3
|
作者：
Nagaraju, Chaithra [1 ]
Ashok, Swarup Hassan [2 ]
Narayana, Yatheesh [1 ]
Nagarakere, Sandhya C. [3 ]
Kempegowda, Mantelingu [1 ]
Kanchugarkoppal, Rangappa S. [1 ]
机构：
[1] Univ Mysore, Synthet Lab, DOS Chem, Mysuru, India
[2] BNM Inst Technol, Dept Chem, Bangalore, Karnataka, India
[3] St Philomenas Coll, PG Dept Chem, Mysuru, India
来源：
SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 23期
关键词：
Amidoximes; catalyst-free; isothiacyanates; S-N bond formation; 1; 2; 4-thiadiazole; BIOLOGICAL EVALUATION; ALLOSTERIC MODULATOR; 1,2,4-THIADIAZOLES; 1,2,4-OXADIAZOLES; DERIVATIVES; SCH-202676; INHIBITORS; SOLVENT;
D O I：
10.1080/00397911.2021.1986840
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A protocol has been devised for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles utilizing isothiocyanates, amidoximes and water as an eco-friendly solvent. The strategy involves consecutive C-N and S-N bonds formation in a one-pot reaction under catalyst-free conditions. Operational simplicity, low cost, broad substrate scope and readily available starting materials are the main features of this protocol.
引用
收藏
页码：3610 / 3619
页数：10
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