Catalyst-free, one-pot strategy to access 3-substituted-5-amino-1,2,4-thiadiazoles in water

被引：3

作者：

Nagaraju, Chaithra ^{[1
]}

Ashok, Swarup Hassan ^{[2
]}

Narayana, Yatheesh ^{[1
]}

Nagarakere, Sandhya C. ^{[3
]}

Kempegowda, Mantelingu ^{[1
]}

Kanchugarkoppal, Rangappa S. ^{[1
]}

机构：

[1] Univ Mysore, Synthet Lab, DOS Chem, Mysuru, India

[2] BNM Inst Technol, Dept Chem, Bangalore, Karnataka, India

[3] St Philomenas Coll, PG Dept Chem, Mysuru, India

来源：

SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 23期

关键词：

Amidoximes; catalyst-free; isothiacyanates; S-N bond formation; 1; 2; 4-thiadiazole; BIOLOGICAL EVALUATION; ALLOSTERIC MODULATOR; 1,2,4-THIADIAZOLES; 1,2,4-OXADIAZOLES; DERIVATIVES; SCH-202676; INHIBITORS; SOLVENT;

D O I：

10.1080/00397911.2021.1986840

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protocol has been devised for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles utilizing isothiocyanates, amidoximes and water as an eco-friendly solvent. The strategy involves consecutive C-N and S-N bonds formation in a one-pot reaction under catalyst-free conditions. Operational simplicity, low cost, broad substrate scope and readily available starting materials are the main features of this protocol.

引用

页码：3610 / 3619

页数：10

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