Therapeutic role of mesenchymal stem cells (MSCs) in diabetic kidney disease (DKD)

被引：6
作者：
Xu, Ning [1 ]
Liu, Jie [1 ]
Li, Xiangling [2 ]
机构：
[1] Weifang Med Univ, Affiliated Hosp, Sch Clin Med, Weifang 261053, Peoples R China
[2] Weifang Med Univ, Dept Nephrol, Affiliated Hosp, Weifang 261031, Peoples R China
来源：
ENDOCRINE JOURNAL | 2022年 / 69卷 / 10期
关键词：
Therapy; Diabetic kidney disease; Mesenchymal stem cells; AMELIORATES GLOMERULAR INJURY; PODOCYTE SLIT DIAPHRAGM; STROMAL CELLS; NEPHROPATHY; TRANSPLANTATION; MELLITUS; HYPERGLYCEMIA; INFUSION; EXOSOMES; POTENCY;
D O I：
10.1507/endocrj.EJ22-0123
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Findings of preclinical studies and recent phase I/II clinical trials have shown that mesenchymal stem cells (MSCs) play a significant role in the development of diabetic kidney disease (DKD). Thus, MSCs have attracted increasing attention as a novel regenerative therapy for kidney diseases. This review summarizes recent literature on the roles and potential mechanisms, including hyperglycemia regulation, anti-inflammation, anti-fibrosis, pro-angiogenesis, and renal function protection, of MSC-based treatment methods for DKD. This review provides novel insights into understanding the pathogenesis of DKD and guiding the development of biological therapies.
引用
收藏
页码：1159 / 1172
页数：14
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