Impact of Combined Transcranial Direct Current Stimulation and Speech-language Therapy on Spontaneous Speech in Aphasia: A Randomized Controlled Double-blind Study

被引:15
作者
Guillouet, Elodie [1 ,2 ]
Cogne, Melanie [3 ]
Saverot, Elisabeth [4 ]
Roche, Nicolas [1 ,5 ]
Pradat-Diehl, Pascale [6 ]
Weill-Chounlamountry, Agnes [6 ]
Ramel, Vanessa [6 ]
Taratte, Catherine [4 ]
Lachasse, Anne-Gaelle [4 ]
Haulot, Jean-Arthur [4 ]
Vaugier, Isabelle [7 ]
Barbot, Frederic [7 ]
Azouvi, Philippe [1 ,2 ]
Charveriat, Sophie [1 ,2 ]
机构
[1] Hop Raymond Poincare, Rehabil Unit, 104 Blvd Raymond Poincare, F-92380 Garches, France
[2] Versailles St Quentin Univ, HANDIReSP, EA4047, F-78180 Versailles, France
[3] Univ Hosp, Rehabil Unit, F-35000 Rennes, France
[4] MGEN, Rehabil Unit, F-78600 Maisons Laffitte, France
[5] Raymond Poincare Teaching Hosp, AP HP,CIC 429,Team 3, Physiol Funct Testing Ward,UVSQ,INSERM Unit 1179, Technol & Innovat Therapies Appl Neuromuscular Di, F-92380 Garches, France
[6] Hop Pitie Salpariere, AP HP, Rehabil Unit, F-75013 Paris, France
[7] Hop Raymond Poincare, AP HP, INSERM, Ctr Invest Clin 1429, F-92380 Garches, France
关键词
Stroke; Language; tDCS; Rehabilitation; Spontaneous discourse; Ecological assessment; BRAIN-STIMULATION; ELECTRICAL-STIMULATION; POSTSTROKE APHASIA; STROKE PATIENTS; VERB RETRIEVAL; TDCS; RECOVERY; DISCOURSE; TMS; REHABILITATION;
D O I
10.1017/S1355617719001036
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Aphasia recovery depends on neural reorganization, which can be enhanced by speech-language therapy and noninvasive brain stimulation. Several studies suggested that transcranial direct current stimulation (tDCS) associated with speech-language therapy may improve verbal performance evaluated by analytic tests, but none focused on spontaneous speech. We explored the effect of bihemispheric tDCS on spontaneous speech in patients with poststroke aphasia. Methods: In this multicentric controlled randomized cross-over double-blind study, we included 10 patients with poststroke aphasia (4 had aphasia >6 months and 6 with aphasia <6 months). We combined the sessions of speech-language therapy and bihemispheric tDCS (2 mA, 20 min). After three baseline speech evaluations (1/week), two different conditions were randomly consecutively proposed: active and sham tDCS over 3 weeks with 1 week of washout in between. The main outcome measure was the number of different nouns used in 2 min to answer the question "what is your job." Results: There was no significant difference between conditions concerning the main outcome measure (p = .47) nor in the number of verbs, adjectives, adverbs, pronouns, repetitions, blank ideas, ideas, utterances with grammatical errors or paraphasias used. Other cognitive functions (verbal working memory, neglect, or verbal fluency) were not significantly improved in the tDCS group. No adverse events occurred. Conclusion: Our results differed from previous studies using tDCS to improve naming in patients with poststroke aphasia possibly due to bihemispheric stimulation, rarely used previously. The duration of the rehabilitation period was short given the linguistic complexity of the measure. This negative result should be confirmed by larger studies with ecological measures.
引用
收藏
页码:7 / 18
页数:12
相关论文
共 79 条
[1]  
AIACH Pierre., 2007, Medicine, VN˚3, P130, DOI DOI 10.1684/MED.2007.0093
[2]   Transcranial direct current stimulation (tDCS) to improve naming ability in post-stroke aphasia: A critical review [J].
ALHarbi, Mohammed F. ;
Armijo-Olivo, Susan ;
Kim, Esther S. .
BEHAVIOURAL BRAIN RESEARCH, 2017, 332 :7-15
[3]  
[Anonymous], TRENDS SPORT SCI
[4]   Using Transcranial Direct-Current Stimulation to Treat Stroke Patients With Aphasia [J].
Baker, Julie M. ;
Rorden, Chris ;
Fridriksson, Julius .
STROKE, 2010, 41 (06) :1229-1236
[5]   Development and Validation of a Stratification Tool for Predicting Risk of Deep Sternal Wound Infection after Coronary Artery Bypass Grafting at a Brazilian Hospital [J].
Barros Oliveira Sa, Michel Pompeu ;
Ferraz, Paulo Ernando ;
Soares, Artur Freire ;
Albuquerque Miranda, Rodrigo Gusmao ;
Araujo, Mayara Lopes ;
Silva, Frederico Vasconcelos ;
Lima, Ricardo de Carvalho .
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY, 2017, 32 (01) :1-7
[6]   Verb retrieval in action naming and spontaneous speech in agrammatic and anemic aphasia [J].
Bastiaanse, R ;
Jonkers, R .
APHASIOLOGY, 1998, 12 (11) :951-969
[7]  
Biga J., 2017, HAUTE AUTORITE SANTE
[8]   Transcranial direct current stimulation in post-stroke aphasia rehabilitation: A systematic review [J].
Biou, Elisa ;
Cassoudesalle, Helene ;
Cogne, Melanie ;
Sibon, Igor ;
De Gabory, Isabelle ;
Dehail, Patrick ;
Aupy, Jerome ;
Glize, Bertrand .
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE, 2019, 62 (02) :104-121
[9]   Speech and language therapy for aphasia following stroke [J].
Brady, Marian C. ;
Kelly, Helen ;
Godwin, Jon ;
Enderby, Pam ;
Campbell, Pauline .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2016, (06)
[10]   tDCS over the motor cortex improves lexical retrieval of action words in poststroke aphasia [J].
Branscheidt, Meret ;
Hoppe, Julia ;
Zwitserlood, Pienie ;
Liuzzi, Gianpiero .
JOURNAL OF NEUROPHYSIOLOGY, 2018, 119 (02) :621-630