Pathogenicity of novel reassortant Eurasian avian-like H1N1 influenza virus in pigs

被引：8

作者：

Sun, Haoran ^{[1
]}

Liu, Jiyu ^{[1
]}

Xiao, Yihong ^{[2
]}

Duan, Yuhong ^{[1
,2
]}

Yang, Jizhe ^{[1
]}

Chen, Yu ^{[1
]}

Yu, Yinghui ^{[1
]}

Li, Han ^{[1
]}

Zhao, Yuzhong ^{[2
]}

Pu, Juan ^{[1
]}

Sun, Yipeng ^{[1
]}

Liu, Jinhua ^{[1
]}

Sun, Honglei ^{[1
]}

机构：

[1] China Agr Univ, Coll Vet Med, Key Lab Anim Epidemiol & Zoonosis, Minist Agr, Beijing 100193, Peoples R China

[2] Shandong Agr Univ, Dept Fundamental Vet Med, Coll Anim Sci & Vet Med, Tai An 271000, Shandong, Peoples R China

来源：

VIROLOGY | 2021年 / 561卷

基金：

中国国家自然科学基金;

关键词：

G4; genotype; Pig; Pathogenicity; Infectivity; A VIRUSES; SWINE; TRANSMISSIBILITY; EVOLUTION; REPLICATION; INFECTION; OUTBREAK; DISEASE; GENES; CHINA;

D O I：

10.1016/j.virol.2021.06.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Reassortant Eurasian avian-like (EA) H1N1 virus, possessing 2009 pandemic (pdm/09) and triple-reassortant (TR)-derived internal genes, namely G4 genotype, has replaced the G1 genotype EA H1N1 virus (all the genes were of EA origin) and become predominant in swine populations in China. Understanding the pathogenicity of G4 viruses in pigs is of great importance for disease control. Here, we conducted comprehensive analyses of replication and pathogenicity of G4 and G1 EA H1N1 viruses in pigs. G4 virus exhibited enhanced replication, increased duration of virus shedding, and caused more severe respiratory lesions in pigs compared with G1 virus. G4 virus, with viral ribonucleoprotein (vRNP) complex genes of pdm/09 origin, exhibited higher levels of nuclear accumulation and higher polymerase activity, which is essential for improved replication of G4 virus. These findings indicate that G4 virus poses a great threat to both swine industry and public health, and control measures should be urgently implemented.

引用

页码：28 / 35

页数：8

共 46 条

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