Achievements and challenges in composite tissue allotransplantation

被引：67

作者：

Schneeberger, Stefan ^{[1
,2
]}

Landin, Luis ^{[3
]}

Jableki, Jerzy ^{[4
]}

Butler, Peter ^{[5
]}

Hoehnke, Christoph ^{[6
]}

Brandacher, Gerald ^{[1
,2
]}

Morelon, Emmanuel ^{[7
]}

机构：

[1] Innsbruck Med Univ, Ctr Operat Med, Dept Visceral Transplant & Thorac Surg, A-6020 Innsbruck, Austria

[2] Johns Hopkins Univ, Sch Med, Dept Plast & Reconstruct Surg, Baltimore, MD USA

[3] La Paz Univ Hosp, Div Plast & Reconstruct Surg, Madrid, Spain

[4] St Jadwiga Hosp, Subdept Replantat Limbs, Trzebnica, Poland

[5] Royal Free Hosp, Dept Plast Surg, London NW3 2QG, England

[6] Univ Munich, Klinikum Memmingen Teaching Hosp, D-80539 Munich, Germany

[7] Univ Lyon, Hosp Civils Lyon, Edouard Herriot Hosp, Dept Transplantat, Lyon, France

来源：

TRANSPLANT INTERNATIONAL | 2011年 / 24卷 / 08期

关键词：

composite tissue transplantation; face transplantation; hand transplantation; indications; outcome; rejection; ABDOMINAL-WALL TRANSPLANTATION; BILATERAL HAND TRANSPLANTATION; UPPER EXTREMITY AMPUTEES; HUMAN FACE ALLOGRAFT; REGULATORY T-CELLS; DONOR BONE-MARROW; MIXED CHIMERISM; RENAL-TRANSPLANTATION; ORGAN-TRANSPLANTATION; FOLLOW-UP;

D O I：

10.1111/j.1432-2277.2011.01261.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Overall, more than 60 hand/forearm/arm transplantations and 16 face transplantations have been performed in the past 12 years. In the European experience summarized here, three grafts have been lost in response to a vascular thrombosis (n = 1), rejection and incompliance with immunosuppression (n = 1) and death (n = 1). The overall functional and esthetic outcome is very satisfactory, but serious side effects and complications related to immunosuppression are challenges hindering progress in this field. The high levels of immunosuppression, skin rejection, nerve regeneration, donor legislation and the acceptance level need to be addressed to promote growth of this promising new field in transplantation and reconstructive surgery.

引用

页码：760 / 769

页数：10

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