Ral GTPases: crucial mediators of exocytosis and tumourigenesis

被引：54
作者：
Shirakawa, Ryutaro [1 ]
Horiuchi, Hisanori [1 ]
机构：
[1] Tohoku Univ, Inst Dev Aging & Canc, Dept Mol & Cellular Biol, Aoba Ku, Sendai, Miyagi 9808575, Japan
来源：
JOURNAL OF BIOCHEMISTRY | 2015年 / 157卷 / 05期
关键词：
exocyst; exocytosis; Ral; Ras; tumourigenesis; GTP-BINDING PROTEIN; NUCLEOTIDE EXCHANGE FACTOR; TUBEROUS SCLEROSIS COMPLEX; VON-WILLEBRAND-FACTOR; WEIBEL-PALADE BODIES; HUMAN TUMOR-CELLS; NF-KAPPA-B; EXOCYST COMPLEX; ACTIVATING PROTEIN; ENDOTHELIAL-CELLS;
D O I：
10.1093/jb/mvv029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Ral guanosine triphosphatases (GTPases), RalA and RalB, are members of the Ras superfamily of small GTPases. Research on Ral GTPases and their functions over the past 25 years has revealed the essential involvement of these GTPases in unique and diverse cellular processes including exocyst-mediated exocytosis and related cellular activities. Moreover, it is increasingly appreciated that the aberrant activation of Ral GTPases is one of the major causes of human tumourigenesis induced by oncogenic Ras. Recent evidence suggests that Ral signalling pathways may be potential therapeutic targets for the treatment of human cancers. This review summarizes recent advance in the investigation of Ral GTPases.
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页码：285 / 299
页数：15
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