Role of the Spacer of cationic gemini amphiphiles in the condensation of DNA

被引：62
|
作者：
Bombelli, C
Borocci, S
Diociaiuti, M
Faggioli, F
Galantini, L
Luciani, P
Mancini, G
Sacco, MG
机构：
[1] Univ Roma La Sapienza, CNR, Ist Metodol Chim, I-00185 Rome, Italy
[2] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy
[3] Univ Tuscia, Dipartimento Sci Ambientali, Ctr Eccellenza Mat Innovativi Nanostruct Applicaz, I-01100 Viterbo, Italy
[4] CNR, Ist Tecnol Biomed, I-20090 Segrate, Italy
[5] Ist Super Sanita, I-00161 Rome, Italy
来源：
LANGMUIR | 2005年 / 21卷 / 23期
关键词：
D O I：
10.1021/la051324+
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The condensation of calf thymus DNA into the cholesteric-like Psi-phase was observed by circular dichroism in liposome suspensions formulated with specific cationic gemini surfactants. The stereochemistry of the gemini spacer, the presence of specific functional groups, and the covalent link between the headgroups are fundamental issues in the condensation of DNA. Transmission electron microscopy images showed a multilamellar morphology, which corresponds with condensation.
引用
收藏
页码：10271 / 10274
页数：4
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