Blood-retinal barrier breakdown in experimental coronavirus retinopathy: association with viral antigen, inflammation, and VEGF in sensitive and resistant strains

被引：33
作者：
Stanley, AV
Wang, Y
Vinores, MA
Derevjanik, NL
Shi, A
Klein, DA
Detrick, B
Hooks, JJ
机构：
[1] Johns Hopkins Univ, Sch Med, Wilmer Ophthalmol Inst, Baltimore, MD 21287 USA
[2] NEI, Immunol & Virol Sect, Immunol Lab, NIH, Bethesda, MD 20892 USA
[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 119卷 / 02期
关键词：
coronavirus; blood-retinal barrier; vascular endothelial growth factor; retinopathy;
D O I：
10.1016/S0165-5728(01)00374-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Intraocular coronavirus inoculation results in a biphasic retinal disease in susceptible mice (BALB/c) characterized by an acute inflammatory response, followed by retinal degeneration associated with autoimmune reactivity. Resistant mice (CD-1), when similarly inoculated, only develop the early phase of the disease. Blood-retinal barrier (BRB) breakdown occurs in the early phase in both strains, coincident with the onset of inflammation. As the inflammation subsides, the extent of retinal vascular leakage is decreased, indicating that BRB breakdown in experimental coronavirus retinopathy (ECOR) is primarily due to inflammation rather than to retinal cell destruction. Vascular endothelial growth factor (VEGF) is upregulated only in susceptible mice during the secondary (retinal degeneration) phase. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：175 / 182
页数：8
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