Issues with using baseline in last observation carried forward analysis

被引：12

作者：

Julious, Steven A. ^{[1
]}

Mullee, Mark A. ^{[2
]}

机构：

[1] Univ Sheffield, Med Stat Grp, Sheffield S1 4DA, S Yorkshire, England

[2] Southampton Gen Hosp, Res & Dev Support Unit, Southampton, England

来源：

PHARMACEUTICAL STATISTICS | 2008年 / 7卷 / 02期

关键词：

LOCF; baselines; missing data; imputation;

D O I：

10.1002/pst.311

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The topic of this paper was prompted by a study for which one of us was the statistician. It was submitted to Annals of Internal Medicine. The paper had positive reviewer comment; however, the statistical reviewer stated that for the analysis to be acceptable for publication, the missing data had to be accounted for in the analysis through the use of baseline in a last observation carried forward imputation. We discuss the issues associated with this form of imputation and recommend that it should not be undertaken as a primary analysis. Copyright (C) 2007 John Wiley & Sons, Ltd.

引用

页码：142 / 146

页数：5

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