In vitro evaluation of 2,4-dihydroxythiobenzanilides against various moulds

被引：27

作者：

Niewiadomy, A ^{[1
]}

Matysiak, J ^{[1
]}

Macik-Niewiadomy, G ^{[1
]}

机构：

[1] Univ Agr, Dept Chem, PL-20950 Lublin, Poland

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2001年 / 13卷 / 03期

关键词：

2,4-dihydroxythiobenzanilides; anti-moulds activity; in vitro study; MIC; lipophilicity;

D O I：

10.1016/S0928-0987(01)00126-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The antimycotic potency of 2,4-dihydroxythiobenzanilide derivatives was tested. The MIC assessments by an agar dilution method were used for the estimation of potential activity in vitro against the four mould strains: Scopulariopsis brevicalis, Aspergillus niger, Aspergillus fumigatus and Penicillium sp. The strongest fungistatic activity was observed for 3 ' -fluoro-derivative (MIC 7.82 mug/ml). It was stated that the inhibition action of these compounds depends mainly on lipophilicity of molecules. Parabolic relationships between the antimycotic activity and lipophilicity were found. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：243 / 248

页数：6

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