Rational design of two-photon absorbing dicyanomethylene-4H-chromene derivatives and their application in bioimaging

被引：17

作者：

Chen, Shuyi ^{[1
]}

Zhang, Mingzhu ^{[1
]}

Zhu, Chuanzhen ^{[1
]}

Lu, Huanxuan ^{[1
]}

Zhao, Meng ^{[1
]}

Tian, Xiaohe ^{[2
]}

Zhang, Qiong ^{[1
]}

De Souza, Senio Campos ^{[3
]}

Rong, Fang ^{[2
]}

Zhou, Hongping ^{[1
]}

Wu, Jieying ^{[1
]}

Tian, Yupeng ^{[1
]}

机构：

[1] Anhui Univ, Dept Chem, Key Lab Funct Inorgan Mat Chem Anhui Prov, Hefei 230601, Anhui, Peoples R China

[2] Anhui Univ, Sch Life Sci, Hefei 230039, Anhui, Peoples R China

[3] UCL, Dept Chem, London WC1H 0AJ, England

来源：

DYES AND PIGMENTS | 2018年 / 148卷

基金：

中国国家自然科学基金;

关键词：

DCM derivatives; Large Stokes-shift; Two-photon absorbing; Biological imaging; Minimal autofluorescence; AMYLOID-BETA PLAQUES; IN-VIVO; FLUORESCENT-PROBES; PHOTOPHYSICAL PROPERTIES; OPTICAL-PROPERTIES; ABSORPTION; MITOCHONDRIA; MICROSCOPY; MOLECULES; ACID;

D O I：

10.1016/j.dyepig.2017.09.047

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In vitro and in vivo fluorescence imaging of cells and animals plays a significant role in studying biological systems. However, autofluorescence becomes a serious issue in vivo imaging under excitation at UV-vis wavelengths where biological molecules cause interference with the chromophore. In order to address this issue, a novel class of dicyanomethylene-4H-chromene (DCM) derivatives (PCM, PCV, BPCM and BPCV) that can be excited at similar to 900 nm under two-photon excitation conditions and emit in the red wavelength region (>= 600 nm) have been developed. Particularly, one of the DCM derivatives (PCM) shows several advantages, including remarkable two-photon absorption (2PA) properties in the near infrared (NIR) region, superior photostability, large Stokes-shift and pronounced solvent-sensitive emission behavior, which is favorable for in vivo fluorescence labelling with a high signal-to-noise ratio. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：429 / 436

页数：8

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