Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity

被引：8
作者：
Khan, Bilour [1 ]
Kafian-Attari, Iman [1 ]
Nippolainen, Ervin [1 ]
Shaikh, Rubina [1 ]
Semenov, Dmitry [2 ]
Hauta-Kasari, Markku [2 ]
Toyras, Juha [1 ,3 ]
Afara, Isaac O. [1 ,3 ]
机构：
[1] Univ Eastern Finland, Dept Appl Phys, Yliopistonranta 1, Kuopio 70120, Finland
[2] Univ Eastern Finland, Sch Comp, Lamsikatu 15, Joensuu 80110, Finland
[3] Univ Queensland, Sch Informat Technol & Elect Engn, St Lucia, Qld 4072, Australia
来源：
BIOMEDICAL OPTICS EXPRESS | 2021年 / 12卷 / 10期
基金：
芬兰科学院; 欧盟地平线“2020”;
关键词：
SPECTROSCOPIC EVALUATION; SCATTERING PROPERTIES; ABSORPTION-SPECTRA; SKIN; INDENTATION; CHONDROCYTE; PARAMETERS; THICKNESS; DEFECTS; WATER;
D O I：
10.1364/BOE.430053
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Optical properties of biological tissues in the NIR spectral range have demonstrated significant potential for in vivo diagnostic applications and are critical parameters for modelling light interaction in biological tissues. This study aims to investigate the optical properties of articular cartilage as a function of tissue depth and integrity. The results suggest consistent wavelength-dependent variation in optical properties between cartilage depth-wise zones, as well as between healthy and degenerated tissue. Also, statistically significant differences (p<0.05) in both optical properties were observed between the different cartilage depth-wise zones and as a result of tissue degeneration. When taken into account, the outcome of this study could enable accurate modelling of light interaction in cartilage matrix and could provide useful diagnostic information on cartilage integrity. (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
引用
收藏
页码：6066 / 6080
页数：15
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