Nonmetastatic breast cancer patients subsequently developing second primary malignancy: A population-based study

被引：13

作者：

Bao, Shengnan ^{[1
,2
]}

Jiang, Mengping ^{[1
,2
]}

Wang, Xi ^{[1
,2
]}

Hua, Yijia ^{[1
,2
]}

Zeng, Tianyu ^{[1
,2
]}

Yang, Yiqi ^{[1
,2
]}

Yang, Fan ^{[1
,2
]}

Yan, Xueqi ^{[1
,2
]}

Sun, Chunxiao ^{[1
]}

Yang, Mengzhu ^{[1
]}

Fu, Ziyi ^{[1
]}

Huang, Xiang ^{[1
]}

Li, Jun ^{[1
]}

Wu, Hao ^{[1
]}

Li, Wei ^{[1
]}

Tang, Jinhai ^{[3
]}

Yin, Yongmei ^{[1
,4
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Clin Coll 1, Nanjing, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Gen Surg, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China

[4] Nanjing Med Univ, Collaborat Innovat Ctr Personalized Canc Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Jiangsu, Peoples R China

来源：

CANCER MEDICINE | 2021年 / 10卷 / 23期

关键词：

breast cancer; breast cancer-specific survival; multiple primary cancer; nomogram; second primary cancer; WOMEN; AGE; RADIATION; MORTALITY; SURVIVAL; THERAPY;

D O I：

10.1002/cam4.4351

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background With life span extending, breast cancer (BC) survivors may face the possibility of developing second primary cancer (SPC) and considerably shorten survivorship. However, little is known about multiple primary cancer (MPC) patients with nonmetastatic breast cancer as a first primary malignancy (BCFPM). Methods Here, we retrospectively analyzed data on cancer survivors with BCFPM diagnosed between 2010 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. The prognostic factors for breast cancer-specific survival (BCSS) were ascertained by the stepwise regression analysis and a competing risk model, and were integrated to the establishment of prognostic nomogram, of which the accuracy was measured by the calibration curve and the concordance index (C-index). Results In total, 8616 patients were identified with 4.6% of 3-year breast cancer- specific death (BCSD) and 8.6% of 5-year BCSD. The most common SPC among BCFPM patients were female BC and lung cancer. Besides, the median latency time between BC and SPC was 22 months. At a ratio of 7:3, all patients were randomly categorized into a training cohort (n = 6032) and a validation cohort (n = 2584). By a proportional subdistribution hazards regression analysis, the following factors were considered to own independent prognostic abilities of BCSS: subtypes, grade, T classification, N classification, radiation, and sites of SPC. The nomogram could accurately predict 3-year and 5-year breast cancer-associated survival of BCFPM patients with high internal and external validated C-index, 0.715 (95% CI, 0.691-0.739), and 0.683 (95% CI, 0.642-0.724), respectively. Conclusions BC survivors remained a high risk of developing SPC and considerably shortened survival time. In this study, a favorable nomogram was constructed to as a prediction model for 3-year and 5-year BCSS of BCFPM patients, largely intending to prolong the life of these patients by assisting clinicians to make individualized follow-up plans.

引用

页码：8662 / 8672

页数：11

共 27 条

[21] Multiple cancer prevalence: A growing challenge in long-term survivorship [J].