Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response

被引：23

作者：

Lopez, Karla E. ^{[1
,2
,3
]}

Bouchier-Hayes, Lisa ^{[1
,2
,3
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Div Hematol Oncol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[3] Texas Childrens Hosp, William T Shearer Ctr Human Immunobiol, Houston, TX 77030 USA

来源：

CELLS | 2022年 / 11卷 / 12期

关键词：

caspases; DNA damage; genomic instability; cell cycle; apoptosis; SINGLE-STRANDED-DNA; GENOMIC INSTABILITY; MEMBRANE PERMEABILIZATION; CHECKPOINT PATHWAY; CELL-DEATH; APOPTOSIS; PROTEIN; CANCER; P53; PHOSPHORYLATION;

D O I：

10.3390/cells11121887

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Members of the caspase family are well known for their roles in the initiation and execution of cell death. Due to their function in the removal of damaged cells that could otherwise become malignant, caspases are important players in the DNA damage response (DDR), a network of pathways that prevent genomic instability. However, emerging evidence of caspases positively or negatively impacting the accumulation of DNA damage in the absence of cell death demonstrates that caspases play a role in the DDR that is independent of their role in apoptosis. This review highlights the apoptotic and non-apoptotic roles of caspases in the DDR and how they can impact genomic stability and cancer treatment.

引用

页数：19

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