Hydrogen Peroxide Activated Matrix Metalloproteinase Inhibitors: A Prodrug Approach

被引：108

作者：

Jourden, Jody L. Major ^{[1
]}

Cohen, Seth M. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 38期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

hydrogen peroxide; matrix metalloproteinases proinhibitors; self-immolative protecting groups; stroke; LIVING CELLS; STROKE; BRAIN; PROBE; MMPS; RATS;

D O I：

10.1002/anie.201003819

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Doing double duty: A metalloproteinase inhibitor that can be activated by reactive oxygen species (ROS) has been designed to protect the blood-brain barrier (BBB) in ischemic reperfusion injury. By both neu-tralizing damaging ROS and inhibiting degradative metalloproteinases, a single compound can eliminate both threats to the BBB upon activation. © 2010 Wiley-VCH Verlag GmbH &. Co. KGaA, Weinheim.

引用

页码：6795 / 6797

页数：3

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