Synthesis of non-C2 symmetrical NOBIN-type biaryls through a cascade N-arylation and [3,3]-sigmatropic rearrangement from O-arylhydroxylamines and diaryliodonium salts

被引：8

作者：

Liu, Fengting ^{[1
]}

Wang, Min ^{[1
]}

Qu, Jiatong ^{[1
]}

Lu, Haifeng ^{[1
]}

Gao, Hongyin ^{[1
]}

机构：

[1] Shandong Univ, Key Lab Colloid & Interface Chem, Minist Educ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 33期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; ENANTIOSELECTIVE ALPHA-ARYLATION; METAL-FREE SYNTHESIS; ONE-POT SYNTHESIS; FACILE SYNTHESIS; PHENOXYACETAMIDES; DERIVATIVES; EFFICIENT; MILD; BOND;

D O I：

10.1039/d1ob00636c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed herein a regioselective construction of non-C-2 symmetrical NOBIN-type biaryls through a cascade N-arylation and [3,3]-sigmatropic rearrangement from O-arylhydroxylamines and diaryliodonium salts under mild conditions. The employment of copper salt could inhibit the further O-arylation of the newly formed biaryl products, otherwise, O-arylated NOBIN-type products were furnished in moderate to good isolated yields. The products of this protocol can be further converted into highly valuable functional molecules and heterocycles.

引用

页码：7246 / 7251

页数：6

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