A new instrument designed to measure the magnetic susceptibility of human liver tissue In vivo

被引:4
作者
Farrell, D. E. [1 ]
Allen, C. J.
Whilden, M. W.
Kidane, T. K.
Baig, T. N.
Tripp, J. H.
Brown, R. W.
Sheth, S.
Brittenham, G. M.
机构
[1] Case Western Reserve Univ, Cleveland, OH 44106 USA
[2] GE Healthcare Technol, Florence, SC 29505 USA
[3] Columbia Univ, New York, NY 10032 USA
基金
美国国家卫生研究院;
关键词
diamagnetic; hepatic iron concentration; high-temperature superconductivity; magnetic susceptibility; paramagnetic; phantom; storage iron; susceptometer;
D O I
10.1109/TMAG.2007.901352
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
All existing superconducting instrumentation for measuring the concentration of iron stored in the human liver requires liquid helium for its operation. We report the mathematical modeling, optimization, and instrumental performance of an instrument that uses high-transition-temperature (high-T-c) superconductors. Requiring only liquid nitrogen to operate, the susceptometer represents the first medical application of the phenomenon of high-temperature superconductivity with the potential for widespread clinical utility.
引用
收藏
页码:3543 / 3554
页数:12
相关论文
共 19 条
  • [1] BAUMAN JH, 1967, J LAB CLIN MED, V70, P246
  • [2] POSSIBLE HIGH-TC SUPERCONDUCTIVITY IN THE BA-LA-CU-O SYSTEM
    BEDNORZ, JG
    MULLER, KA
    [J]. ZEITSCHRIFT FUR PHYSIK B-CONDENSED MATTER, 1986, 64 (02): : 189 - 193
  • [3] NONINVASIVE METHODS FOR THE EARLY DETECTION OF HEREDITARY HEMOCHROMATOSIS
    BRITTENHAM, GM
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1988, 526 : 199 - 208
  • [4] MAGNETIC-SUSCEPTIBILITY MEASUREMENT OF HUMAN IRON STORES
    BRITTENHAM, GM
    FARRELL, DE
    HARRIS, JW
    FELDMAN, ES
    DANISH, EH
    MUIR, WA
    TRIPP, JH
    BELLON, EM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1982, 307 (27) : 1671 - 1675
  • [5] EFFICACY OF DEFEROXAMINE IN PREVENTING COMPLICATIONS OF IRON OVERLOAD IN PATIENTS WITH THALASSEMIA MAJOR
    BRITTENHAM, GM
    GRIFFITH, PM
    NIENHUIS, AW
    MCLAREN, CE
    YOUNG, NS
    TUCKER, EE
    ALLEN, CJ
    FARRELL, DE
    HARRIS, JW
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (09) : 567 - 573
  • [6] Liver iron concentration evaluated by two magnetic methods: Magnetic resonance imaging and magnetic susceptometry
    Carneiro, AAO
    Fernandes, JP
    de Araujo, DB
    Elias, J
    Martinelli, ALC
    Covas, DT
    Zago, MA
    Angulo, IL
    St Pierre, TG
    Baffa, O
    [J]. MAGNETIC RESONANCE IN MEDICINE, 2005, 54 (01) : 122 - 128
  • [7] Superconducting quantum interference device instruments and applications
    Fagaly, R. L.
    [J]. REVIEW OF SCIENTIFIC INSTRUMENTS, 2006, 77 (10)
  • [8] A CLINICAL-SYSTEM FOR ACCURATE ASSESSMENT OF TISSUE IRON CONCENTRATION
    FARRELL, DE
    TRIPP, JH
    BRITTENHAM, GM
    DANISH, EH
    HARRIS, JW
    TRACHT, AE
    [J]. NUOVO CIMENTO DELLA SOCIETA ITALIANA DI FISICA D-CONDENSED MATTER ATOMIC MOLECULAR AND CHEMICAL PHYSICS FLUIDS PLASMAS BIOPHYSICS, 1983, 2 (02): : 582 - 593
  • [9] MAGNETIC MEASUREMENT OF HUMAN IRON STORES
    FARRELL, DE
    TRIPP, JH
    ZANZUCCHI, PE
    HARRIS, JW
    BRITTENHAM, GM
    MUIR, WA
    [J]. IEEE TRANSACTIONS ON MAGNETICS, 1980, 16 (05) : 818 - 823
  • [10] FARRELL DE, UNPUB IEEE T MAGN