Palladium-catalyzed ortho-C(sp2)-H bromination of benzaldehydes via a monodentate transient directing group strategy

被引：15

作者：

Yong, Qiyun ^{[1
]}

Sun, Bing ^{[1
]}

Zhang, Fang-Lin ^{[1
]}

机构：

[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Hubei, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 46期

基金：

中国国家自然科学基金;

关键词：

Palladium; Monodentate; Transient directing group; Benzaldehyde; SUZUKI-MIYAURA; COUPLING REACTIONS; HALOGENATION; FUNCTIONALIZATION; CHLORINATION; BROMPERIDOL; BROMHEXINE; AROMATICS; EFFICIENT;

D O I：

10.1016/j.tetlet.2019.151263

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient monodentate transient directing group strategy was developed to enable the palladium-catalyzed ortho-C(sp(2))-H bromination of benzaldehydes. A broad scope of benzaldehydes were transformed into the desired products by employing 2-amino-5-chlorobenzotrifluoride as a monodentate transient directing group, demonstrating good functional group tolerance. Mild reaction conditions and no requirement for a silver salt are also features of this strategy. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页数：4

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