Soluble versus insoluble polymers as supports for the preparation of new glycosteroids -: a practicability study

被引：0

作者：

Jesberger, M

Jaunzems, J

Jung, A

Jas, G

Schönberger, A

Kirschning, A

机构：

[1] Tech Univ Clausthal, Inst Organ Chem, D-38678 Clausthal Zellerfeld, Germany

[2] AnalytiCon AG Biotechnol Pharm Potsdam, D-14476 Potsdam, Germany

来源：

SYNLETT | 2000年 / 09期

关键词：

natural product; linker; solid phase synthesis; glycosteroid;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two polymeric supports along with two different linkers for attachment to O-4 of carbohydrate-derived glycals were evaluated for the solid phase synthesis of new glycosteroids 9 and 16. From these studies it can be concluded that soluble MPEG-ethers are less well suited polymeric supports for automated synthesis of glycoconjugates. Furthermore, it was found that glycosylation proceeds with much higher selectivity with polymer-bound glycals 3a and 12 compared to the solution variant.

引用

页码：1289 / 1293

页数：5