The Wnt7's Tale: A story of an orphan who finds her tie to a famous family

被引：23

作者：

Noda, Makoto ^{[1
]}

Vallon, Mario ^{[2
]}

Kuo, Calvin J. ^{[2
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Mol Oncol, Kyoto 6068501, Japan

[2] Stanford Univ, Sch Med, Dept Med, Div Hematol, Stanford, CA 94305 USA

来源：

CANCER SCIENCE | 2016年 / 107卷 / 05期

基金：

日本学术振兴会; 美国国家卫生研究院;

关键词：

Angiogenesis; Gpr124; Reck; Wnt7a/b; zebrafish; TUMOR-SUPPRESSOR PROTEIN; COUPLED RECEPTOR; WNT/BETA-CATENIN; CNS ANGIOGENESIS; DOWN-REGULATION; INHIBITOR RECK; BETA-CATENIN; GPR124; METALLOPROTEINASE; INVOLVEMENT;

D O I：

10.1111/cas.12924

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The transformation suppressor gene RECK was isolated by cDNA expression cloning (1998), and GPR124/TEM5 was detected as a tumor endothelial marker by differential screening (2000). The importance of Wnt7a /b and Gpr124 in brain angiogenesis was demonstrated by reverse genetics in mice (2008-2010). A series of recent studies using genetically engineered mice and zebrafish as well as luciferase reporter assays in cultured cells led to the discovery of functional interactions among Reck, Gpr124, and Wnt7a /b in triggering canonical Wnt signaling with relevance to embryonic brain angiogenesis and blood-brain barrier formation.

引用

页码：576 / 582

页数：7