The Wnt7's Tale: A story of an orphan who finds her tie to a famous family

被引：23
作者：
Noda, Makoto [1 ]
Vallon, Mario [2 ]
Kuo, Calvin J. [2 ]
机构：
[1] Kyoto Univ, Grad Sch Med, Dept Mol Oncol, Kyoto 6068501, Japan
[2] Stanford Univ, Sch Med, Dept Med, Div Hematol, Stanford, CA 94305 USA
来源：
CANCER SCIENCE | 2016年 / 107卷 / 05期
基金：
日本学术振兴会; 美国国家卫生研究院;
关键词：
Angiogenesis; Gpr124; Reck; Wnt7a/b; zebrafish; TUMOR-SUPPRESSOR PROTEIN; COUPLED RECEPTOR; WNT/BETA-CATENIN; CNS ANGIOGENESIS; DOWN-REGULATION; INHIBITOR RECK; BETA-CATENIN; GPR124; METALLOPROTEINASE; INVOLVEMENT;
D O I：
10.1111/cas.12924
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The transformation suppressor gene RECK was isolated by cDNA expression cloning (1998), and GPR124/TEM5 was detected as a tumor endothelial marker by differential screening (2000). The importance of Wnt7a /b and Gpr124 in brain angiogenesis was demonstrated by reverse genetics in mice (2008-2010). A series of recent studies using genetically engineered mice and zebrafish as well as luciferase reporter assays in cultured cells led to the discovery of functional interactions among Reck, Gpr124, and Wnt7a /b in triggering canonical Wnt signaling with relevance to embryonic brain angiogenesis and blood-brain barrier formation.
引用
收藏
页码：576 / 582
页数：7
相关论文
共 51 条
  • [1] Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor
    Anderson, Keith D.
    Pan, Li
    Yang, Xiao-man
    Hughes, Virginia C.
    Walls, Johnathon R.
    Dominguez, Melissa G.
    Simmons, Mary V.
    Burfeind, Patricia
    Xue, Yingzi
    Wei, Yi
    Macdonald, Lynn E.
    Thurston, Gavin
    Daly, Christopher
    Lin, Hsin Chieh
    Economides, Aris N.
    Valenzuela, David M.
    Murphy, Andrew J.
    Yancopoulos, George D.
    Gale, Nicholas W.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (07) : 2807 - 2812
  • [2] Carson-Walter EB, 2001, CANCER RES, V61, P6649
  • [3] Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice
    Chandana, Ediriweera P. S.
    Maeda, Yasuhiro
    Ueda, Akihiko
    Kiyonari, Hiroshi
    Oshima, Naoko
    Yamamoto, Mako
    Kondo, Shunya
    Oh, Junseo
    Takahashi, Rei
    Yoshida, Yoko
    Kawashima, Satoshi
    Alexander, David B.
    Kitayama, Hitoshi
    Takahashi, Chiaki
    Tabata, Yasuhiko
    Matsuzaki, Tomoko
    Noda, Makoto
    [J]. BMC DEVELOPMENTAL BIOLOGY, 2010, 10
  • [4] RECK - a newly discovered inhibitor of metastasis with prognostic significance in multiple forms of cancer
    Clark, Jonathan C. M.
    Thomas, David M.
    Choong, Peter F. M.
    Dass, Crispin R.
    [J]. CANCER AND METASTASIS REVIEWS, 2007, 26 (3-4) : 675 - 683
  • [5] GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier
    Cullen, Mike
    Elzarrad, Mohammed K.
    Seaman, Steven
    Zudaire, Enrique
    Stevens, Janine
    Yang, Mi Young
    Li, Xiujie
    Chaudhary, Amit
    Xu, Lihong
    Hilton, Mary Beth
    Logsdon, Daniel
    Hsiao, Emily
    Stein, Erica V.
    Cuttitta, Frank
    Haines, Diana C.
    Nagashima, Kunio
    Tessarollo, Lino
    St Croix, Brad
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (14) : 5759 - 5764
  • [6] Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis
    Daneman, Richard
    Agalliu, Dritan
    Zhou, Lu
    Kuhnert, Frank
    Kuo, Calvin J.
    Barres, Ben A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (02) : 641 - 646
  • [7] Critical roles for murine Reck in the regulation of vascular patterning and stabilization
    de Almeida, Glicia Maria
    Yamamoto, Mako
    Morioka, Yoko
    Ogawa, Shuichiro
    Matsuzaki, Tomoko
    Noda, Makoto
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [8] Keeping Wnt Signalosome in Check by Vesicular Traffic
    Feng, Qiang
    Gao, Nan
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2015, 230 (06) : 1170 - 1180
  • [9] Diverse Roles for Wnt7a in Ventral Midbrain Neurogenesis and Dopaminergic Axon Morphogenesis
    Fernando, Chathurini V.
    Kele, Julianna
    Bye, Christopher R.
    Niclis, Jonathan C.
    Alsanie, Walaa
    Blakely, Brette D.
    Stenman, Jan
    Turner, Brad J.
    Parish, Clare L.
    [J]. STEM CELLS AND DEVELOPMENT, 2014, 23 (17) : 1991 - 2003
  • [10] FAK and WNT Signaling: The Meeting of Two Pathways in Cancer and Development
    Fonar, Yuri
    Frank, Dale
    [J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2011, 11 (07) : 600 - 606
123456