Population Genomics and Inference of Mycobacterium avium Complex Clusters in Cystic Fibrosis Care Centers, United States

被引：28

作者：

Hasan, Nabeeh A. ^{[1
]}

Davidson, Rebecca M. ^{[1
]}

Epperson, L. Elaine ^{[1
]}

Kammlade, Sara M. ^{[1
]}

Beagle, Sean ^{[1
]}

Levin, Adrah R. ^{[1
]}

de Moura, Vinicius Calado ^{[1
]}

Hunkins, Joshua J. ^{[1
]}

Weakly, Natalia ^{[1
]}

Sagel, Scott D. ^{[2
,3
]}

Martiniano, Stacey L. ^{[2
,3
]}

Salfinger, Max ^{[4
,5
]}

Daley, Charles L. ^{[1
]}

Nick, Jerry A. ^{[1
]}

Strong, Michael ^{[1
]}

机构：

[1] Natl Jewish Hlth, Denver, CO 80206 USA

[2] Univ Colorado, Anschutz Med Campus, Aurora, CO USA

[3] Childrens Hosp Colorado, Aurora, CO USA

[4] Univ S Florida, Coll Publ Hlth, Tampa, FL USA

[5] Univ S Florida, Morsani Coll Med, Tampa, FL 33620 USA

来源：

EMERGING INFECTIOUS DISEASES | 2021年 / 27卷 / 11期

基金：

美国国家卫生研究院;

关键词：

SUBSP HOMINISSUIS; HOUSEHOLD WATER; NONTUBERCULOUS MYCOBACTERIA; GENETIC DIVERSITY; LUNG-DISEASE; INTRACELLULARE; INFECTION; CHIMERA; DIAGNOSIS; SEQUENCE;

D O I：

10.3201/eid2711.210124

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium avium complex (MAC) species constitute most mycobacteria infections in persons with cystic fibrosis (CF) in the United States, but little is known about their genomic diversity or transmission. During 2016-2020, we performed whole-genome sequencing on 364 MAC isolates from 186 persons with CF from 42 cystic fibrosis care centers (CFCCs) across 23 states. We compared isolate genomes to identify instances of shared strains between persons with CF. Among persons with multiple isolates sequenced, 15/56 (27%) had >1 MAC strain type. Genomic comparisons revealed 18 clusters of highly similar isolates; 8 of these clusters had patients who shared CFCCs, which included 27/186 (15%) persons with CF. We provide genomic evidence of highly similar MAC strains shared among patients at the same CFCCs. Polyclonal infections and high genetic similarity between MAC isolates are consistent with multiple modes of acquisition for persons with CF to acquire MAC infections.

引用

页码：2836 / 2846

页数：11

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