Niphatoxin C, a cytotoxic tripyridine alkaloid from Callyspongia sp.

被引：22

作者：

Buchanan, Malcolm S. ^{[1
]}

Carroll, Anthony R. ^{[1
]}

Addepalli, Rama ^{[1
]}

Avery, Vicky M. ^{[1
]}

Hooper, John N. A. ^{[2
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Queensland Museum, Queensland Ctr Biodivers, Brisbane, Qld 4101, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 12期

关键词：

D O I：

10.1021/np070366q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

As part of our studies to discover P2X(7) receptor antagonists, the sponge Callyspongia sp. was investigated. A new tripyridine alkaloid niphatoxin C (1) was isolated and had P2X(7) receptor antagonism; however, cytotoxicity of THP-1 cells was the predominant biological effect at higher concentrations. Its structure was determined by 1- and 2-D NMR spectroscopy.

引用

页码：2040 / 2041

页数：2

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