Complexes with biologically active ligands .3. Synthesis of coordination compounds of chlorothiazide with divalent metal ions

被引：0

作者：

Supuran, CT ^{[1
]}

机构：

[1] UNIV FLORENCE, LAB INORGAN & BIOINORGAN CHEM, I-50121 FLORENCE, ITALY

来源：

MAIN GROUP METAL CHEMISTRY | 1996年 / 19卷 / 06期

关键词：

CARBONIC-ANHYDRASE INHIBITORS; HETEROCYCLIC SULFONAMIDES; DUAL INHIBITORS; ACETAZOLAMIDE;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Complexes of chlorothiazide (6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide) - a widely used diuretic and antihypertensive agent - with divalent metal ions (Be(II): Mg(II); Zn(II); Cd(II); Hg(II) and Pb(II) ) were prepared and characterized by elemental analysis, spectroscopic. thermogravimetric, and conductimetric measurements. The complexes were tested as inhibitors of the enzyme carbonic anhydrase (CA).

引用

页码：347 / 353

页数：7

共 36 条

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