Antifibrotic effects of D-limonene (5(1-methyl-4-[1-methylethenyl]) cyclohexane) in CCl4 induced liver toxicity in Wistar rats

被引：36

作者：

Ahmad, Sheikh Bilal ^{[1
]}

Rehman, Muneeb U. ^{[1
]}

Fatima, Bilques ^{[1
]}

Ahmad, Bilal ^{[1
]}

Hussain, Ishraq ^{[1
]}

Ahmad, Sheikh Pervaiz ^{[2
]}

Farooq, Adil ^{[3
]}

Muzamil, Showkeen ^{[1
]}

Razzaq, Rahil ^{[1
]}

Rashid, Shahzada Mudasir ^{[1
]}

Bhat, Showkat Ahmad ^{[1
]}

Mir, Manzoor Ur Rahman ^{[1
]}

机构：

[1] Sheri Kashmir Univ Agr Sci & Technol SKUAST K, Fac Vet Sci & Anim Husb, Div Vet Biochem, Mol Biol Lab, Srinagar 190006, Jammu & Kashmir, India

[2] Univ Kashmir, Dept Stat, Hazratbal Srinagar 190006, Jammu & Kashmir, India

[3] RAK Med & Hlth Sci Univ, RAKCOPS, Ras Al Khaymah 11172, U Arab Emirates

来源：

ENVIRONMENTAL TOXICOLOGY | 2018年 / 33卷 / 03期

关键词：

antifibrotic; CCL4; D-Limonene; fibrosis and liver; FACTOR-KAPPA-B; CARBON-TETRACHLORIDE; INDUCED HEPATOTOXICITY; OXIDATIVE STRESS; FIBROSIS; CANCER; INFLAMMATION; MECHANISM; CITRUS; CARCINOGENESIS;

D O I：

10.1002/tox.22523

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study was designed to assess the potential antifibrotic effect of D-Limonenea component of volatile oils extracted from citrus plants. D-limonene is reported to have numerous therapeutic properties. CCl4-intduced model of liver fibrosis in Wistar rats is most widely used model to study chemopreventive studies. CCl4-intoxication significantly increased serum aminotransferases and total cholesterol these effects were prevented by cotreatment with D-Limonene. Also, CCl4-intoxication caused depletion of glutathione and other antioxidant enzymes while D-Limonene preserved them within normal values. Hydroxyproline and malondialdehyde content was increased markedly by CCl4 treatment while D-Limonene prevented these alterations. Levels of TNF-alpha, TGF-beta, and alpha-SMA were also assessed; CCl4 increased the expression of alpha-SMA, NF-kappa B and other downstream inflammatory cascade while D-Limonene co-treatment inhibited them. Collectively these findings indicate that D-Limonene possesses potent antifibrotic effect which may be attributed to its antioxidant and anti-inflammatory properties.

引用

页码：361 / 369

页数：9

共 63 条

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