Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals

被引：7
作者：
Laplana, Marina [1 ]
Fibla, Joan [1 ]
机构：
[1] Univ Lleida, Dept Ciencies Med Basiques, Unitat Genet Humana, IRBLleida, Lleida 25008, Spain
来源：
CYTOKINE | 2012年 / 58卷 / 01期
关键词：
RANTES; CCR5; Polymorphism; Inflammation; Longevity; LONGEVITY; ATHEROSCLEROSIS; MEN;
D O I：
10.1016/j.cyto.2011.12.021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although persistent inflammation has been related to unsuccessful aging, a pro-inflammatory status is the common phenotype in older people. To assess for a genetic component in the inflammatory status of the oldest we studied the distribution of two polymorphic chemokine pathway genes, RANTES and CCR5, in elderly. RANTES -403G/A and RANTES Int1.1T/C polymorphisms and CCR5 Delta 32 polymorphism were genotyped in 104 elderly and 110 controls. RANTES -403A and RANTES Int1.1C alleles have been associated with pro-inflammatory and anti-inflammatory status, respectively. CCR5 Delta 32 abrogates functional receptor expression of the pro-inflammatory CCR5-mediated action. Prevalence of RANTES -403G allele, associated in other studies with high RANTES production, was reduced in elderly males, compared with controls. In addition, RANTES pro-inflammatory haplotype -403A-Int1.1T was overrepresented in elderly males, while RANTES anti-inflammatory haplotype -403G-Int1.1C was overrepresented in elderly females. Our results suggest a sex-specific RANTES inflammatory genetic determinant that could contribute to the known sex-related differences in aging. (C) 2012 Elsevier Ltd. All rights reserved.
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收藏
页码：10 / 13
页数：4
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