A Protocol for an Asymmetric Synthesis of γ-Amino Acids

被引：20

作者：

Reddy, Leleti Rajender ^{[1
]}

Prasad, Kapa ^{[1
]}

Prashad, Mahavir ^{[1
]}

机构：

[1] Novartis Pharmaceut, Chem & Analyt Dev, E Hanover, NJ 07936 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 14期

关键词：

TERT-BUTANESULFINYL IMINES; X-RAY-CRYSTAL; BETA-PEPTIDES; NMR-SOLUTION; DESIGN; DERIVATIVES; REDUCTION; PYRROLIDINES; LIGANDS; ESTERS;

D O I：

10.1021/jo301177f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and practical method for the asymmetric synthesis of gamma-amino acids from beta,gamma-butenolides by an in situ esterification, condensation, and reduction in a one-pot procedure is described. This method is quite general for the preparation of both enantiomers of aryl or aliphatic gamma-amino acids in high yields. These gamma-amino-acid derivatives were also shown to be versatile synthetic intermediates for further transformations by their conversion to gamma-lactams, delta-amino alcohols, and hydrolysis products in high yields with no racernization.

引用

页码：6296 / 6301

页数：6

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