Stawamycin analog, JBIR-11 from Streptomyces viridochromogenes subsp sulfomycini NBRC 13830

被引：3

作者：

Izumikawa, Miho ^{[2
]}

Komaki, Hisayuki ^{[3
]}

Hashimoto, Junko ^{[2
]}

Takagi, Motoki ^{[2
]}

Shin-ya, Kazuo ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Biol Informat Res Ctr, Koto Ku, Tokyo 1350064, Japan

[2] Japan Biol Informat Consortium, Japan Biol Informat Res Ctr, Koto Ku, Tokyo 1350064, Japan

[3] Natl Inst Technol & Evaluat, NITE Biol Resource Ctr, Chiba 2920818, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 05期

关键词：

stawamycin; JBIR-11; Streptomyces viridochromogenes; cytotoxic;

D O I：

10.1038/ja.2008.47

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A stawamycin analog, JBIR-11 (1) was isolated from mycelium of Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830. The structure was determined on the basis of the spectroscopic data. Compound 1 exhibited growth inhibitory effect against human fibrosarcoma HT 1080 cells with an IC50 value of 25 mu M.

引用

页码：326 / 329

页数：4

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