Potent and Selective Tyk2 Inhibitor Highly Efficacious in Rodent Models of Inflammatory Bowel Disease and Psoriasis

被引:0
|
作者
Miao, Wenyan [1 ]
Masse, Craig [1 ]
Greenwood, Jeremy [2 ]
Kapeller, Rosana [1 ]
Westlin, William [1 ]
机构
[1] Nimbus Therapeut, Cambridge, MA USA
[2] Schrodinger Inc, New York, NY USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1911
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis
    Leit, Silvana
    Greenwood, Jeremy R.
    Mondal, Sayan
    Carriero, Samantha
    Dahlgren, Markus
    Harriman, Geraldine C.
    Kennedy-Smith, Joshua J.
    Kapeller, Rosana
    Lawson, Jon P.
    Romero, Donna L.
    V. Toms, Angela
    Shelley, Mee
    Wester, Ronald T.
    Westlin, William
    McElwee, Joshua J.
    Miao, Wenyan
    Edmondson, Scott D.
    Masse, Craig E.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 73
  • [2] Characterization of ARTS-011, a potent and selective TYK2 inhibitor for the treatment of inflammatory disease
    Liang, Jiaqi
    Liu, Yiting
    Zhang, Xiaobin
    Zhang, Tao
    Liu, Xipan
    Fu, Jia
    Cheng, Dai
    Xiong, Wen
    Ding, Peter
    Zhu, Cong
    Li, Fang
    Chen, Yaoyu
    JOURNAL OF IMMUNOLOGY, 2022, 208 (01):
  • [3] Discovery of a Potent and Subtype-Selective Tyk2 Degrader Based on an Allosteric Tyk2 Inhibitor
    Kato, Jun-Ya
    Korenaga, Shigeru
    Iwakura, Masaru
    SSRN, 2022,
  • [4] Discovery of a potent and subtype-selective TYK2 degrader based on an allosteric TYK2 inhibitor
    Kato, Jun-ya
    Korenaga, Shigeru
    Iwakura, Masaru
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 79
  • [5] Preclinical Profiles of FZ007-119, a Highly Potent and Selective Tyk2 Inhibitor, for the Treatment of Immune Mediated Inflammatory Diseases
    Zhong, Wenhe
    Lu, Jielian
    Chen, Dong
    Zhang, Shiqun
    Deng, Daiguo
    ARTHRITIS & RHEUMATOLOGY, 2023, 75 : 2224 - 2225
  • [6] Design of a potent and selective dual JAK1/TYK2 inhibitor
    Mammoliti, Oscar
    Menet, Christel
    Cottereaux, Celine
    Blanc, Javier
    De Blieck, Ann
    Coti, Ghjuvanni
    Geney, Raphael
    Oste, Line
    Ostyn, Koen
    Palisse, Adeline
    Quinton, Evelyne
    Schmitt, Benoit
    Borgonovi, Monica
    Parent, Isabelle
    Jagerschmidt, Catherine
    De Vos, Steve
    Vayssiere, Beatrice
    Lopez-Ramos, Miriam
    Shoji, Kenji
    Brys, Reginald
    Amantini, David
    Galien, Rene
    Joannesse, Caroline
    BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 114
  • [7] Therapeutic potential of a synthetic dual JAK1/TYK2 inhibitor in inflammatory bowel disease
    Cui, Xue
    Teng, Yaxin
    Hu, Yiguo
    Li, Qingqing
    Pei, Heying
    Yang, Zhuang
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 126
  • [8] BMS-986165 IS A HIGHLY POTENT AND SELECTIVE ALLOSTERIC INHIBITOR OF TYK2, BLOCKS IL-12, IL-23 AND TYPE I INTERFERON SIGNALING AND PROVIDES FOR ROBUST EFFICACY IN PRECLINICAL MODELS OF INFLAMMATORY BOWEL DISEASE
    Xie, Jenny H.
    Gillooly, Kathleen
    Zhang, Yifan
    Yang, Xiaoxia
    Zupa-Fernandez, Adriana
    Cheng, Lihong
    Strnad, Joann
    Heimrich, Elizabeth
    Zhou, Xiaodi
    Chen, Jing
    Chaudhry, Charu
    Li, Sha
    Moslin, Ryan
    Wrobleski, Stephen
    Burke, James
    GASTROENTEROLOGY, 2018, 154 (06) : S1357 - S1357
  • [9] Selective JAK1 inhibitor and selective Tyk2 inhibitor patents
    Norman, Peter
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2012, 22 (10) : 1233 - 1249
  • [10] Selective Tyrosine Kinase 2 (TYK2) Inhibition in Plaque Psoriasis
    Kircik, Leon
    Aldredge, Lakshi M.
    DiRuggiero, Douglas
    JOURNAL OF DRUGS IN DERMATOLOGY, 2024, 23 (08) : 645 - 652